膀胱癌患者Ⅱ型环氧合酶和血管内皮生长因子的表达及意义  

Expression of Cyclooxygenase2 and Vascular Endothelial Growth Factor in Bladder Transitional Cell Carcinoma

作　　者：沈军[1] 夏宏辉[1] 王开昕[2] 方建民[1] 谢磊[1] 李文杰[1] 虞晓勇[1] 王可兵[1] 

机构地区：[1]广东医学院附属南山医院泌尿外科,广东深圳518052 [2]广东医学院附属南山医院病理科

出　　处：《临床泌尿外科杂志》2010年第4期253-255,共3页Journal of Clinical Urology

摘　　要：目的:探讨Ⅱ型环氧合酶(Cox-2)和血管内皮生长因子(VEGF)的表达与膀胱移行细胞癌(BTCC)生物学行为的关系。方法:应用免疫组化方法对139例BTCC以及36例正常膀胱组织中的Cox-2和VEGF进行检测。结果:Cox-2的阳性率在T_(a～1)和T_(2～4)分别为34.3%和75.0%(P<0.001);Ⅰ级和Ⅲ级的表达率分别为33.9%和81.8%(P<0.001)。VEGF的阳性表达率在T_(a～1)和T_(2～4)分别为23.9%和79.2%(P<0.001);Ⅰ级和Ⅲ级的表达率分别为32.2%和84.8%(P<0.001)。BTCC组织中COX-2与VEGF表达呈正相关(r=0.607,P<0.05)。结论:Cox-2和VEGF可以作为了解BTCC生物学行为的有效指标。Objective：To study the relationship between the expression of Cox-2 and VEGF and the biological behavior of bladder transitional cell carcinoma. Methods：The expressions of Cox-2 and VEGF were studied by immunohistochemistry in 139 cases of bladder cancer , 36 cases of normal bladder tissue. Results：The positive rate of Cox-2 in different group were as follow ： T0-1 34.3% , T2-4 75.0% （P〈 0. 05）, the expression rate were Ⅰ 33.90/00, Ⅲ 81.8% （P〈0.05）. The positive rate of VEGF in different group were as follow： Ta-1 23.9% ,T2-4 79.2% （P〈0. 05） ,the expression rate were Ⅰ 32.2%, Ⅲ 84.8% （P〈0.05）. The expression of Cox-2 was posi- tively correlated with that of VEGF（ r= 0. 607, P〈0. 05）. Conclusions：The expression of Cox-2 and VEGF may be parameters for understanding the biological behavior of bladder transitional cell carcinoma.

关 键 词：膀胱移行细胞癌 环氧合酶 血管内皮生长因子 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]