MASPIN基因在妊娠滋养细胞肿瘤中的表达及意义  

The Expression of MASPIN in Gestational Trophoblastic Tumor and Its Significance

作　　者：田腊梅[1] 庞义存[1] 冯玉珍[1] 赵向寨[1] 赵欢[1] 

机构地区：[1]河北医科大学第三医院妇产科,石家庄050051

出　　处：《国际妇产科学杂志》2010年第3期219-220,F0003,共3页Journal of International Obstetrics and Gynecology

基　　金：国家自然基金(30772317);河北省科技厅科研基金资助项目(09276101D-30)

摘　　要：目的:探讨MASPIN基因在妊娠滋养细胞肿瘤中的表达,了解MASPIN基因在妊娠滋养细胞肿瘤发生、发展中的作用。方法:采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接(SP)法检测10例妊娠滋养细胞肿瘤、30例葡萄胎、20例正常妊娠早期绒毛(对照组)各标本中MASPIN的表达。结果:妊娠滋养细胞肿瘤中MASPIN阳性表达率(10%,1/10)明显低于对照组(95%,19/20)(P<0.05)。葡萄胎组中MASPIN阳性表达率(60%,18/30)明显低于对照组(95%,19/20)(P<0.05)。妊娠滋养细胞肿瘤中MASPIN阳性表达率明显低于葡萄胎组(P<0.05)。结论:MASPIN的表达下调与妊娠滋养细胞疾病的发生、发展有关,可能是妊娠滋养细胞疾病发病的重要机制之一。Objective： To investigate the expression of MASPIN in gestational trophoblastic tumor （GTT）, and the role of MASPIN in GTT. Methods： Forty inpatients with gestational trophoblastic disease （GTD） were recruited in the study, including 30 patients with hydatidiform mole, 10 with GTT. and 20 normal chorion were taken as control. Immunohistochemistry was used to analyze MASPIN expression in GTD and normal chorion. Results： The gestational trophoblastic tumor MASPIN positive expression rate （10%, 1/10） was significantly lower than the control group （95%, 19/20）, the two groups, the difference was statistically significant （P 〈0.05 ）. Hydatidiform mole group MASPINpositive rate （60%, 18/30） was significantly lower than the control group （95%, 19/20）, （P〈0.05）. Gestational trophoblastie tumor MASPIN expression was significantly lower than that of hydatidiform mole group （P 〈 0.05 ）. Conclusion： The down-regulation of the MASPIN expression is involved in the development of GTD, and may paly an important role in the pathogenesis of GTD.

关 键 词：妊娠滋养细胞肿瘤 葡萄胎 MASPIN基因 侵袭性 免疫组织化学 丝氨酸蛋白酶抑制剂 

分 类 号：R737.33[医药卫生—肿瘤]