阿尔茨海默病和血管性痴呆患者血浆同型半胱氨酸和胆碱酯酶水平及其临床意义探讨  

Homocysteine and cholinesterase levels of the AD & VaD patients and their clinical meanings investigation

作　　者：蒋安杰[1] 方芳[1] 晏勇[2] 魏祥松[3] 吴瑾[1] 李梁蜜[1] 唐多荣[1] 李承[1] 颜因[1] 

机构地区：[1]重庆市第九人民医院神经内科,400700 [2]重庆医科大学附属第一医院神经内科,400016 [3]重庆市第九人民医院检验科,400700

出　　处：《重庆医学》2010年第12期1530-1532,共3页Chongqing medicine

基　　金：重庆市卫生局课题资助项目(06-2-186)

摘　　要：目的检测阿尔茨海默病(AD)和血管性痴呆(VaD)患者血浆中同型半胱氨酸、叶酸、维生素B12和胆碱酯酶水平,探讨其临床意义。方法选取AD30例、VaD32例和正常对照31例,用化学免疫发光法测定受试对象血浆中同型半胱氨酸、叶酸、维生素B12水平,用酶学法测定胆碱酯酶水平。结果与对照组比较,AD组和VaD组患者血浆中同型半胱氨酸明显升高(P<0.01),叶酸和维生素B12水平明显下降(P<0.01);AD组患者血浆中胆碱酯酶明显降低(P<0.01)。结论测定血浆中同型半胱氨酸、叶酸、维生素B12和胆碱酯酶水平,对诊断AD和VaD提供帮助;补充叶酸和维生素B12有望改善痴呆患者的临床症状。Objective To detect the homocysteine,folic acid,vitamin B12,and cholinesterase levels of the AD and VaD patients,and to investigate their clinical meanings.Methods 30 AD,32 VaD,and 31 normal patients have been chosen respectively,and by the means of chemoimmunology and enzymology,the Hcy,FOL,VitB12,ChE levels of each patient have been detected.Results Compared with the normal group,the Hcy levels of AD and VaD patients increased markedly（P0.01）,on the contrary,the FOL,VitB12 levels decreased significantly（P0.01）;Furthermore,the ChE level of the AD patients decreased obviously （P0.01）.Conclusion It is very helpful for the diagnosis of AD and VaD by detecting the Hcy,FOL,VitB12,ChE of the patients;the clinical symptom of the dementia patients can be improved by adding the FOL and VitB12 levels.

关 键 词：同型半胱氨酸 胆碱酯酶 阿尔茨海默病 血管性痴呆 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]