含β-丙氨酸的双链寡聚酰胺的合成  

Synthesis of hairpin-polyamides containing β-alanine

作　　者：李鹏[1] 姜志辉[1] 邱财荣[2] 谢伟杰[1] 祝绍隆[1] 王亮[1] 张大志[1] 

机构地区：[1]第二军医大学药学院有机化学教研室,上海200433 [2]解放军第三医院药剂科,陕西宝鸡721004

出　　处：《药学实践杂志》2010年第3期217-219,231,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金资助项目(NO.30672533);军队"十一五"课题06H013

摘　　要：目的建立分子内含β-丙氨酸的双链寡聚酰胺的合成新方法和策略。方法通过优化硝基氢化还原的方法,采用2+2片段偶合的策略,以1-羟基苯并三唑(HOBT)/N,N'-二环乙基碳酰亚胺(DCC)为缩合剂进行双链寡聚酰胺的合成。结果高产率合成出了双链寡聚酰胺分子NO2ImPyβImPyγImPyβPyPyβCOOC2H5。结论通过对反应温度、反应溶剂以及片段的选择优化,可以简便有效地合成分子内含有β-丙氨酸的双链寡聚酰胺。Objective To develop a new method and strategy for the synthesis of hairpin-polyamides containingβ-alanine.Methods The hairpin-polyamides were synthesized by the HOBT/DCC coupling reaction in good yields through the optimization of hydrogenation of nitro group and the 2＋2 fragment coupling strategy.Results A hairpin-polyamide NO2ImPyβImPyγImPyβPyPyβCOOC2H5 was synthesized successfully with good yield.Conclusion The hairpin-polyamides containing β-alanine in the molecular can be easily and efficiently synthesized through the optimization of reaction temperature,solvent and fragment coupling strategy.

关 键 词：Β-丙氨酸 寡聚酰胺 N-甲基吡咯 N-甲基咪唑 合成 

分 类 号：TQ460.31[化学工程—制药化工]