CBS基因多态性与中国人缺血性脑卒中关系的Meta分析  

Correlation of Cystathionine β Synthase Gene Polymorphisms and Risk of Cerebral Arterial Thrombosis in Chinese Population:A Meta-Analysis

作　　者：吕雅丽[1] 李俊枝[1] 米明仁[1] 魏虹霞 刘学东[2] 

机构地区：[1]西安市铁路中心医院老年病科,西安710054 [2]第四军医大学西京医院神经内科,西安710032

出　　处：《中国循证医学杂志》2010年第6期674-677,共4页Chinese Journal of Evidence-based Medicine

摘　　要：目的探讨中国汉族人群胱硫醚β合成酶(cystathionine β synthase,CBS)基因T833C、844ins68多态性与缺血性脑卒中发病的相关性。方法电子检索1999年1月～2009年2月CBM、CNKI、万方数据库、VIP及PubMed,收集有关中国人CBS基因T833C、844ins68多态性与缺血性脑卒中的病例-对照研究。评价纳入研究质量,提取有效数据,采用RevMan4.2软件进行Meta分析。结果共纳入4个研究CBS基因T833C多态性与缺血性脑卒中关系的病例对照研究。山东亚组中以TT型基因为参照,携带CT+CC基因型个体发生缺血性脑卒中风险增高[OR=5.01,95%CI(2.63,9.53),P<0.00001];非山东亚组中携带CT+CC基因型个体发生缺血性脑卒中的风险无明显增高[OR=0.95,95%CI(0.60,1.50),P=0.82]。对844ins68多态性与缺血性脑卒中发病相关性的Meta分析结果表明,以DD基因为参照,携带DI、II基因型的个体发生缺血性脑卒中风险差异无统计学意义[OR=1.20,95%CI(0.72,1.99),P=0.49]。结论中国汉族人群中CBST833C基因多态性可能与山东人缺血性脑卒中发病相关,增加山东人群患缺血性脑卒中的危险性,而与其他省份汉族人群缺血性脑卒中发病可能不相关;CBS844ins68多态性可能与中国汉族人群缺血性脑卒中发病不相关。Objective To investigate the association of the polymorphism of the cystathionine β synthase（CBS） T833C,CBS 844ins68 and cerebral arterial thrombosis in Chinese population.Methods We electronically searched CBM,CNKI,Wanfang database,VIP and PubMed from 1999 to February 2010 to collect case studies on CBS polymorphism and cerebral arterial thrombosis of the Chinese.We evaluated the quality of the included studies and the extracted data.RevMan 4.2 was used for meta-analyses.Results We identified 4 case-control studies on association of CBS T833 polymorphism and cerebral arterial thrombosis of the Chinese.In Shandong subgroup,the Chinese people with TC＋CC genotypes of T833C had higher risk of cerebral arterial thrombosis at OR 5.01 and 95%CI 2.63 to 9.53（P〈0.000 01）.In non-Shandong subgroup,higher risk of cerebral arterial thrombosis was found in the Chinese people with genotype of CT＋CC at OR 0.95 and 95%CI 0.60 to 1.50（P=0.82）.Meta-analyses of the 4 case studies showed there were no significant differences in the risk of cerebral arterial thrombosis between people with genotype of DI and II and people with genotype of DD at OR 1.20 and 95%CI 0.72 to 1.99（P=0.49）.Conclusion Our findings suggest that in Chinese population,CBS T833C polymorphisms might be associated with cerebral arterial thrombosis in Shandong subgroup;844ins68 polymorphisms does not increase the risk of cerebral arterial thrombosis for the Chinese.

关 键 词：胱硫醚Β合成酶 缺血性脑卒中 基因多态性 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]