低频经颅磁刺激对锂-匹罗卡品致痫大鼠痫性发作的影响  

The effect of low-frequency transcranial magnetic stimulation on epilepsy behavior in epilepsy rats induced by lithium-pilocarpine

作　　者：赵红宁[1] 王晓明[1] 张军强[1] 余巨明[1] 赵晓琼[1] 黄敏[1] 黄慧[1] 胡建秀[1] 

机构地区：[1]川北医学院附属医院神经内科、神经电生理研究室,四川南充637000

出　　处：《癫痫与神经电生理学杂志》2010年第3期129-131,135,共4页Journal of Epileptology and Electroneurophysiology(China)

基　　金：四川省青年基会资助项目（NO：04ZQ026-010）,四川省重点科技资助项目（川科计2005-14号）

摘　　要：目的：探讨低频经颅磁刺激（TMS）对癫痫大鼠痫性发作的影响。方法：对50只大鼠进行TMS，根据不同刺激频率将大鼠随机分为5个组（每组10只）：0Hz组（假刺激组）、0．3Hz组、0．5Hz组、0．8Hz组、1．0Hz组，分组进行低频重复TMS预处理后，制作氯化锂一匹罗卡品癫痫模型，观察各组造模后70min内痼性发作的潜伏期和痫性发作行为表现。结果：0．3Hz组、0．5Hz组、0．8Hz组及1．0Hz组的痫性发作潜伏期[分别为（16．30±3．10）min、（18．60±3．50）min、（16．40±3．60）min和（15．90±4．10）mini，均比0Hz组[（12．80±3．20）mini延长，差异均有统计学意义（P〈0．05或P〈0．01），其中0．5Hz组最长；0．5Hz组大鼠出现的痫性行为表现为点头和（或）甩尾、须动和（或）头面抽动、前肢和（或）后肢抽动、全身抽动、窜动的次数均比0．3Hz组、0．8Hz组、1．0Hz组少，整体发作程度轻，差异有统计学意义（P〈0．05）。结论：适量的低频的TMS可延缓癫痫发作潜伏期、减少癫痫发作次数以及减轻癫痫发作程度，具有抗痢作用。Objective： To study the effects of Low-frequency transcranial magnetic stimulation （TMS） on epileptic attack behavior in experimental rats with epilepsy. Methods： According to TMS fraquecy,50 rats were randomly divided into five groups （10 each）. The acute epilepsy model was made with lithium-pilocarpine after pretreatment, and the latency and the behaviors were observed in epilepsy seizures within 70 minutes after intraperitoneal injection of pilocarpine. Results： The latency of the 0.3 Hz,0.5 Hz,0.8 Hz and 1.0 Hz TMS groups was all longer than that of the 0 Hz（pseudostimulation） group（P〈0.05 or P〈0.01）. The frequency of epileptic attack in the 0.5 Hz TMS group including nodding/tail-flick, beard shaking,anterior/hind limb tic, systemic tie and jumps was less than that of the other group respect/v-ely （P〈0.05 or P〈0.01） ,and the attack degree was less than those in the that model group too（P〈0.05）. Conclusion： Appropriate TMS of low-frequency can prolong the latentcy of epilepsy attack,diminish the symptom and degree of epilepsy seizure,and has conspicuous anti-epilepsy effect.

关 键 词：经颅磁刺激(TMS) 癫痫 潜伏期 痫性发作 氯化锂-匹罗卡品 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]