长期接触有机磷农药机体抗氧化能力调查  

Investigation on antioxidant ability in farmers long-term exposed to organophosphorus pesticide

作　　者：李鹏[1] 尹雅玲[2] 詹合琴[1] 王倩倩[1] 朱茉莉[1] 梁金英[1] 赵繁荣[1] 

机构地区：[1]新乡医学院药学院,河南新乡453003 [2]新乡医学院基础医学院,453003

出　　处：《中国职业医学》2010年第3期206-207,210,共3页China Occupational Medicine

基　　金：河南省教育厅2010年度自然科学研究计划项目(2010B330002);河南省重点学科开放性课题(D200906)

摘　　要：目的调查农民长期接触有机磷(OP)农药后机体抗氧化能力的改变。方法随机抽取新乡市4区8县农村地区有长期接触OP农药史的农民382人,分别检测体内丙二醛(MDA)和超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化物酶(LPO)的水平和活力。结果接触OP农药>10年的农民机体抗氧化能力明显下降,但下降程度无年限差异。结论农民长期接触OP农药会引起机体抗氧化能力下降。Objective To investigate the antioxidant ability in the farmers long-term exposed to organophosphorus pesticide.Methods 382 farmers long-term exposed to organophosphorus pesticide from 4 regions and 8 counties in Xinxiang city were randomized into the study.The concentration of MDA,SOD,GSH-Px and LPO were detected.Results The antioxidant abili-ty was lower in exposed group than that in the normal control group,but the decreased degree of oxidation resistance was not correlated with the exposure year in the exposed group.Conclusion Antioxidant ability in farmers long-term exposed to the organophosphorus pesticide was decreased.

关 键 词：有机磷 农药 抗氧化能力 

分 类 号：R135.1[医药卫生—劳动卫生]