低剂量5-Fu长期持续静滴治疗晚期恶性肿瘤  

Long Term Continuous Intravenous Drip Infusion of Low-Dose of 5-Fluorouracil for Advanced Malignant Tumors

作　　者：陈红涛[1] 张红雨[2] 彭培健[2] 肖妹[2] 

机构地区：[1]中山大学附属第五医院肿瘤检验科,广东省珠海市519000 [2]中山大学附属第五医院肿瘤化疗科,广东省珠海市519000

出　　处：《中华全科医学》2010年第7期843-844,共2页Chinese Journal of General Practice

摘　　要：目的观察低剂量5-氟尿嘧啶(5-Fu)长期持续静滴治疗常规含5-Fu类方案失败的晚期恶性肿瘤的近期疗效和毒副反应。方法 19例经传统的含5-Fu类方案化疗失败的晚期恶性肿瘤患者,给予5-Fu200mg/(m2.d)微量泵持续静脉滴注,治疗至疾病进展,每30d后以RECIST评价标准评价疗效,以NCI抗癌药物毒副反应0～Ⅳ级评价毒性反应。结果全组19例均可评价,其中完全缓解(CR)0例,部分缓解(PR)2例,稳定(SD)8例,进展(PD)9例,有效率(RR)10.5%,临床获益率(CR+PR+SD)52.6%。毒副反应主要是Ⅰ～Ⅱ级胃肠道反应及手足综合征。结论低剂量5-氟尿嘧啶长期持续静滴治疗常规含5-Fu类方案失败的晚期恶性肿瘤的近期疗效较好,毒副反应较低,值得进一步研究应用。Objective To investigate the clinical outcome and toxicity of long term continuous infusion（CI）of low dose of 5-FU for the patients who were relapsed or resistant to short term continuous infusion 5-Fu or xeloda-based chemotherapy.Methods 19 patients who were relapsed or resistant to short term continuous infusion 5-Fu or xeloda-based chemotherapy were subjected to long term CI 200 mg/（m^2·d）5-FU through portable pumps until disease progression.After each 30-day course of the treatment,the efficacy and toxicity were evaluated by Response Evaluation Criteria in Solid Tumors（RECIST）and the NCI anticancer drug toxicity criteria,respectively.Results Among all the 19 evaluable cases,there were 0 complete remission（CR）,2 partial remission（PR）,8 stable disease（SD）,and 9 progressive disease（PD）.The response rate（RR=CR＋PR）and the clinical benefit rate（CR＋PR＋SD）were therefore 10.5% and 52.6%,respectively.Toxicities were mainly grade Ⅰ-Ⅱ mucositis and hand-foot syndrome.Conclusion The long term protracted CI of low-dose 5-FU has a better effect on refractory or relapsed patients failed to 5-Fu or xeloda-based chemotherapy.

关 键 词：低剂量5-氟尿嘧啶 持续静滴 难治或复发肿瘤 

分 类 号：R730.53[医药卫生—肿瘤]