胎盘特异性基因PLAC1与肿瘤  

Placenta-specific gene PLAC1 and tumor

作　　者：闫光华[1] 罗彬[1] 肖绍文[1] 谢小薰[1] 

机构地区：[1]广西医科大学组织学与胚胎学教研室,南宁530021

出　　处：《生命的化学》2010年第3期459-463,共5页Chemistry of Life

基　　金：国家自然科学基金资助项目(No.30760055);广西教育厅研究生教育创新计划项目(No.2009105981001M190);广西高发疾病研究创新性团队基金资助项目(No.桂教人[2007-59]号)资助

摘　　要：胎盘特异性基因PLAC1(placenta-specific 1 gene)具有癌-睾丸(cancer-testis antigen,CT)抗原的特点,即能在多种肿瘤组织中表达,而在正常组织(除胎盘和睾丸)几乎不表达。PLAC1编码一种膜蛋白,该蛋白质具有一定的免疫原性,能在肿瘤患者体内引起体液免疫和细胞免疫。目前的研究结果显示PLAC1代表一类新的肿瘤相关抗原,可能成为肿瘤免疫治疗的一个靶点。Placenta-specific gene PLAC1 is characterized by cancer-testis antigen,which is frequently expressed in different types of tumors while it is hardly expressed in normal tissues（except for placenta and testis）.PLAC1 encodes a membrane protein that is immunogenic and is capable of eliciting immune responses in tumor patients.The current results reveal that PLAC1 represents a new class of tumor associated antigen and it is a promising target for tumor immunotherapy.

关 键 词：PLAC1 胎盘特异性基因 肿瘤免疫治疗 

分 类 号：R730.2[医药卫生—肿瘤]