癫痫与细胞因子  

Epilepsy and cytokines

作　　者：黄昱[1] 柳永[1] 唐小龙[1] 刘万红[1] 何小华[1] 

机构地区：[1]武汉大学基础医学院过敏与免疫相关疾病湖北省重点实验室,武汉430071

出　　处：《生命的化学》2010年第3期475-479,共5页Chemistry of Life

基　　金：教育部新世纪优秀人才支持计划(No.NCET-07-0630);留学回国人员科研启动基金;国家自然科学基金(No.30770734)项目支持

摘　　要：细胞因子是由多种细胞,特别是免疫细胞所产生的,具有广泛生物学活性的小分子蛋白质。它们通过与靶细胞表面的特异性受体的结合而发挥作用。研究表明,癫痫患者细胞因子水平与健康人相比发生明显变化。癫痫发作早期,脑内的细胞因子迅速增加,表明了脑内启动了免疫应答,处于炎性状态,有利于机体恢复正常的生理状态;但是,结肠炎、肺炎、类风湿关节炎等炎性环境下却更易诱发癫痫的发生。因此,炎性细胞因子、生长因子在癫痫中可能具有双重作用。本文通过综述癫痫中细胞因子水平的变化,进一步揭示细胞因子在癫痫发病中的作用。Cytokines are produced by many kinds of cells,especially the immune cells.Cytokines that have strong biological activities bind to the specific receptors on target cell surface.Studies have shown that the expression levels of cytokines in patients with epilepsy compared with healthy people change significantly.Under normal circumstances,brain tissue seldom expresses cytokines.But cytokines have been shown to be overexpressed in early seizures.This result showed the brain in inflammatory state started the immune response,which was helpful for returning the normal physiological state.However,some predispositions may induce seizures during inflammatory conditions like colitis,pneumonia and rheumatoid arthritis.So the inflammatory cytokines and growth factors may play dual roles in affecting seizure susceptibility.The roles of cytokines in epilepsy are reviewed in this article.

关 键 词：癫痫 细胞因子 发病机制 

分 类 号：R742.1[医药卫生—神经病学与精神病学]