高尔基体蛋白73与肝癌诊断  

GP73 and hepatocellular carcinoma diagnosis

作　　者：姚西宁[1] 王清明[1] 

机构地区：[1]蛋白质组学国家重点实验室,北京蛋白质组研究中心,军事医学科学院放射与辐射医学研究所,北京102206

出　　处：《生命的化学》2010年第3期480-483,共4页Chemistry of Life

基　　金：国家重大科学研究计划资助项目(2006CB910803)资助

摘　　要：肝癌是我国最常见的恶性肿瘤之一,血清甲胎蛋白(α-fetoprotein,AFP)检查是目前肝癌诊断最常采用的手段,但血清AFP对肝癌诊断的灵敏度和特异性均不理想,因此,临床上迫切需要更理想的肝癌标志物。高尔基体蛋白73(Golgi protein 73,GP73)是一种II型高尔基体跨膜糖蛋白,与肝炎、肝硬化和肝癌等肝病的发生、发展密切相关,GP73对肝癌诊断的灵敏度和特异性为65%和90%,而核心岩藻糖化GP73对肝癌诊断的灵敏度和特异性则高达90%和100%。GP73有可能成为一种更理想的肝癌临床诊断标志物,而核心岩藻糖化的GP73在肝癌的早期诊断中可能具有更重要的意义。Hepatocellular carcinoma（HCC） is the most common cancer in China.Serum α-fetoprotein（AFP） is the most widely common used tumor marker in clinical diagnosis of HCC,but its sensitivity and specificity is not ideal.So it is urgent to discover better HCC markers.Golgi protein 73（GP73） is a resident Golgi type II transmembrane glycoprotein,and was found to be closely related to genesis and development of liver fibrosis,cirrhosis and HCC.GP73 had a sensitivity of 65% and a specificity of 90% in diagnosis of HCC,while fucosylated GP73 had much higher sensitivity（90%） and specificity（100%）.GP73 is most likely to be a promising serum marker for diagnosis of HCC,whereas fucosylated GP73 may have important significance in early diagnosis of HCC.

关 键 词：GP73 肝癌 早期诊断 肝癌标志物 

分 类 号：R735.7[医药卫生—肿瘤]