乳腺浸润性导管癌超声声像与分子免疫学指标检测相关性探讨  

Relation between the sonograpic features of IDC and immunohistochemistical factors

作　　者：谭旭艳[1] 吴丹[1] 高志刚[1] 

机构地区：[1]江苏省肿瘤医院超声科,江苏南京210009

出　　处：《中国肿瘤外科杂志》2010年第3期142-145,共4页Chinese Journal of Surgical Oncology

基　　金：江苏省科技厅自然科学基金项目(BK2009447)

摘　　要：目的探讨乳腺浸润性导管癌(IDC)超声声像与分子免疫学指标——雌激素受体(ER)、孕激素受体(PR)、人类上皮生长因子受体(CerbB-2)表达水平的关系。方法回顾性总结98例IDC超声图像特征,并与经超声引导下自动活检(USGAB)术穿刺活检分子免疫组化结果ER、PR、CerbB-2表达行相关性分析。结果ER、PR、CerbB-2分组结果显示:肿瘤边缘毛刺征组ER表达阳性率明显高于无边缘毛刺征组,差异有统计学意义(P<0.01);肿瘤微钙化组PR表达阳性率明显高于无微钙化组,差异有统计学意义(P<0.01);周边高回声晕组及边缘毛刺征组PR表达阳性率高于周边无高回声晕组及无边缘毛刺征组,差异有统计学意义(P<0.05);肿瘤微钙化组、腋窝肿大淋巴结组CerbB-2表达阳性率明显高于肿瘤内无微钙化组、腋窝无肿大淋巴结组,差异有统计学意义(P<0.01)。结论IDC超声声像特征与ER、PR、CerbB-2表达水平有一定相关性,部分超声征象可能对其生物学特性有提示和评估的意义。Objective To observe the relationship between sonographic features of IDC and immunohisto- chemistical factors （ER, PR, cerbB-2）. Methods Retrospectively reviewed the sonographie features of IDC in 98 patients, analyzed correlation relationship between sonographic features detected by USGAB and the posi- tive rate of ER, PR and cerbB-2 determined by immunohistochemistical technique. Results Positive rate of ER with spicular signs was significantly higher than without lesions （ P 〈 0.01 ） ; PR with mierocaleificatations was significantly higher than without lesions （ P 〈 0.01 ） ; PR with surrounding hyperechoic halo and spicular signs was significantly higher than without lesions （ P 〈 0.05 ） ; cerbB-2 with microcalcificatations and lymph- adenectasis in axillary were significantly higher than without lesions （P 〈 0.01 ）. Conclusions The sonograph- ic features of IDC has correlation to the expression of ER. PR and cerbB-2.

关 键 词：浸润性导管癌 超声声像特征 分子免疫学指标 

分 类 号：R737.9[医药卫生—肿瘤]