HLA-G~＊0105N（rs41557518）多态性与新疆哈萨克族食管癌遗传易感性的研究  

Relationship between the polymorphism of HLA-G~＊0105N（rs41557518） and the susceptibility of esophageal cancer in Kazakh nationality in Xinjiang

作　　者：高秀静[1] 陈艳[1,2] 阿合力.马斯肉拉 王洪疆[3] 邓彦超[4,2] 马彦清[5] 张慧霞[6] 王莹[3] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]新疆食管癌研究所,新疆乌鲁木齐830011 [3]新疆医科大学附属肿瘤医院,新疆乌鲁木齐830011 [4]新疆医科大学第一附属医院,新疆乌鲁木齐830011 [5]新疆伊犁州友谊医院,新疆伊宁835000 [6]新疆医科大学,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2010年第4期343-345,349,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金项目(30460118)

摘　　要：目的初步探讨人类白细胞抗原G(human leukocyte antigen G,HLA-G)*0105N基因(rs 41557518)多态性与新疆哈萨克族(哈族)食管癌遗传易感性的关系。方法采用病例-对照研究方法 ,调查新疆地区哈族食管癌患者132例(病例组)和健康对照254例(对照组),应用PCR-RFLP方法检测HLA-G*0105 N(rs 41557518)多态性。结果基因型C/-、C/C-、/-,在病例组中的频率分别为8.33%、91.67%、0%,在对照组中的频率分别为11.95%、88.05%、0%。两组间基因型频率分布差异无统计学意义(χ2=1.19,P>0.05)。结论 HLA-G*0105 N多态性与新疆哈族食管癌遗传易感性无相关性。Objective To determine the association between the human leukocyte antigen G（HLA-G）＊0105 N（rs 41557518） polymorphism and the susceptibility of esophageal cancer in Kazakh in Xinjiang.Methods A case control study was conducted.The polymorphism of HLA-G＊0105 N（rs 41557518） was analyzed by PCR-RFLP methods in 132 cases of esophageal cancer and 254 healthy controls of Kazakh nationality in Xinjiang area.Results（1） The frequencies of HLA-G＊0105 N genotypes,C/-,C/C,-/-were 8.33%,91.67%,0% and 11.95%,88.05%,0% in Kazakh＇s cases and controls respectively.There was no significant difference in the frequencies of HLA-G＊0105 N genotypes between cases and controls（χ2=1.19,P0.05）.Conclusion HLA-G＊0105 N polymorphism is not associated with the susceptibility of esophageal cancer in Kazakh nationality in Xinjiang.

关 键 词：HLA-G 食管癌 遗传易感性 基因多态性 哈萨克族 

分 类 号：R730.2[医药卫生—肿瘤] R735.1[医药卫生—临床医学]