石榴花提取物对2型糖尿病大鼠胸腺指数和血清白介素6的影响  

Effects of PFE on thymus index and IL-6 of type 2 diabetes rats

作　　者：窦勤[1] 魏媛媛[2] 李郁[1] 闫冬[1] 阿迪力[1] 李潇[1] 蒋磊[1] 帕尔哈提.克热木 

机构地区：[1]新疆医科大学药理学教研室,新疆乌鲁木齐830011 [2]新疆医科大学生理学教研室,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2010年第5期496-498,共3页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区科技攻关(含重大专项)和重点项目计划(200733146)

摘　　要：目的通过石榴花提取物(Pomegranate Flower Extract,PFE)对2型糖尿病(T2DM)大鼠空腹血糖(FPG)、血清胰岛素、炎症因子白介素-6(IL-6)和胸腺指数的影响,研究PFE对糖尿病大鼠免疫功能的影响。方法采用高热量饲料加小剂量链脲佐菌素建立实验性2型糖尿病大鼠模型,分别用石榴花提取物100 mg/kg和300 mg/kg治疗4周后,处死大鼠,测定空腹血糖(FPG)和血清胰岛素水平(INS),白介素-6(IL-6)的含量,计算胸腺指数、胰岛素敏感性指数(ISI),推断对T2DM大鼠免疫功能的影响。结果石榴花提取物能显著降低2型糖尿病大鼠的空腹血糖,显著增加ISI。降低血清炎症因子IL-6并提高胸腺指数。结论石榴花提取物可降低2型糖尿病大鼠的空腹血糖,降低血清炎症因子IL-6的含量并提高胸腺指数。Objective To study the protective effect of pomegranate flower extracts（PFE） on rats with STZ-induced type 2 diabetes mellitus.Methods Rats with STZ-induced type 2 diabetes were established with high calorie feeding and small dose injection of STZ,then treated with PFE for 4 weeks.The FPG,ISI,thymus index and IL-6 were detected.Result： Oral administration of PFG at doses of 100 mg/kg and 300 mg/kg for 28 days resulted in a significant reduction in FPG and IL-6,coupled with elevation of ISI and thymus index in comparison with diabetic control group.Conclusion The results suggest that PFE could be used in the treatment of inflammation of T2DM.

关 键 词：石榴花提取物 2型糖尿病 胰岛素 IL-6 胸腺指数 

分 类 号：R-332[医药卫生] R392.12