新型含哌嗪基的喹啉衍生物的抑菌活性研究  

Antibacterial Activity of Novel Quinoline Derivatives Containing Piperazine

作　　者：吴利欢[1] 邓琪[1] 周秋谷[1] 

机构地区：[1]肇庆学院化学化工学院,广东肇庆526060

出　　处：《广东工业大学学报》2010年第2期40-42,共3页Journal of Guangdong University of Technology

基　　金：广东省自然科学基金资助重点项目(8251063101000002);肇庆市科技计划创新项目(2009G12)

摘　　要：为了寻找高效抑菌活性的新型药物,考察了13种含哌嗪基的喹啉衍生物对大肠杆菌、枯草杆菌、金黄色葡萄球菌的体外抗菌活性.结果表明:化合物3i、3j对大肠杆菌、枯草杆菌、金黄色葡萄球菌均有良好的抗菌效果,最低抑菌质量浓度为0.07 mg/mL.To develop novel antibacterial medicinals with high activity,antibacterial tests of 13 novel quinoline derivatives containing piperazine were conducted.The experimental results show that the compounds 3i and 3j possess good antibacterial activity against Escherichia coli,Bacillus subtilis and Staphylococcus aureus,and their MICs are 0.07 mg/mL.

关 键 词：喹啉 哌嗪 抑菌活性 

分 类 号：O626.323[理学—有机化学]