实验用食蟹猴生物学指标的研究  

STUDY ON BIOLOGICAL PARAMETERS FOR MACACA FASCICULARIS IN EXPERIMENT

作　　者：李岩[1] 何君[1] 孙井江[1] 马耀文[1] 高虹[1] 

机构地区：[1]中国医学科学院医学实验动物研究所,北京100050

出　　处：《现代预防医学》2010年第13期2503-2505,共3页Modern Preventive Medicine

基　　金：医科院国际标准药物安全评价技术平台建设(2008ZX09305001)

摘　　要：[目的]提供实验用食蟹猴的正常生理生化、免疫学、脑脊液指标的参考值。[方法]选取50只4～7岁食蟹猴,雌性24只,雄性26只,分别检测其生理学(心电图、体温、心率)、血液学(血常规、凝血酶原时间)、血液生化学、免疫学(CD3+、CD4+、CD8+、IgG、IgM)和脑脊液(白细胞、葡萄糖、蛋白质、氯化物)指标,并进行性别间比较。[结果]雌雄性动物相比,血常规指标中WBC差异有统计学意义(P﹤0.01);血生化指标中ALP、CHO、CRE、GLU差异有统计学意义(P﹤0.05);免疫学指标中IgM差异有统计学意义(P﹤0.01);脑脊液指标中蛋白质含量差异有统计学意义(P﹤0.05)。其余各检测指标差异无统计学意义(P﹥0.05)。[结论]本研究提供了食蟹猴生理生化、免疫学、脑脊液的背景数据,为其在生物医学领域的应用提供参考。[Objective] To provide reference of physiology,blood biochemistry,immunology and cerebrospinal fluid parameters for Macaca fascicularis.[Methods] 50 Macaca fascicularis aged from 4 to 7（24 were females and 26 were males） were involved in our study.We detected their physiology（ECG,body temperature,heart rate）,hematology（blood routine,prothrombin time）,blood biochemistry,immunology（CD3＋,CD4＋,CD8＋,IgG,IgM） and cerebrospinal fluid（white blood cells,glucose,protein,Cl-） parameters respectively and compared these parameters between males and females.[Results] Between males and females,there were significant differences in WBC of hematology（P﹤0.01） and ALP,CHO,CRE,GLU of blood biochemistry（P﹤0.05）;and significant difference in IgM of immunology（P﹤0.01） and protein of cerebrospinal fluid（P﹤0.05）.There were no significant difference in other parameters（P﹥0.05）.[Conclusion] It provides reference of physiology,blood biochemistry,immunology and cerebrospinal fluid parameters of Macaca fascicularis,and basis for their application in biomedical domain.

关 键 词：食蟹猴 血液学 血液生化 免疫学 脑脊液 

分 类 号：R-332[医药卫生]