在脑瘫发生过程中血清IL-10水平的变化及临床意义  

The Change in serum level of IL-10 and its clinical significance in the course of cerebral palsy's occurrence

作　　者：张鸿[1] 文芳[2] 陶维元[1] 吴擎[1] 

机构地区：[1]武汉大学人民医院神经内科,硕士研究生430060 [2]武汉大学人民医院神经精神病研究所

出　　处：《卒中与神经疾病》2010年第3期163-165,共3页Stroke and Nervous Diseases

摘　　要：目的通过动态观察脐血、新生儿、脑瘫患儿血清白细胞介素-10(Interleukin-10,IL-10)水平的变化与脑损伤及预后的关系。方法采用双抗体夹心酶联免疫吸附试验法(ABC-ELISA)检测脑瘫组、脑瘫高危因素胎儿组(胎儿脐血病例组)、新生儿组(新生儿病例组)及相应对照组血清IL-10水平。结果胎儿脐血病例组血清IL-10水平与胎儿脐血对照组比较有统计学差异(P<0.01),新生儿病例组血清IL-10水平高于新生儿对照组(P<0.01);脑瘫组血清IL-10水平明显高于脑瘫对照组(P<0.01),脑瘫组血清IL-10水平明显高于新生儿病例组、胎儿脐血病例组(P<0.01)。结论 IL-10可以作为急性应激的生物学指标;IL-10水平反映脑损伤的严重程度,监测IL-10对预防和治疗脑瘫具有重要的临床意义。Objective To explore the relationship between interleukin-10（IL-10） and brain injury or its prognosis by dynamic observation of serum IL-10 levels of fetuses,neonates and children with cerebral palsy（CP）.Methods Serum samples of 44 CP patients,16 fetuses and 12 neonates who suffered asphyxia and/or infection and 15 control were obtained respectively and kept at-40℃ until the time of measurement.IL-10 level was measured by the enzyme-linked immunosorbent assay double sandwich method（ABC-ELISA） retrospectively.Results The level of IL-10 in fetuses with CP risk factors was higher than that in the fetuse control group（P0.01）.IL-10 Level of neonates with CP risk factors was higher than that in neonate control group（P0.01）;IL-10 level of CP patients was significantly higher than those of controls、neonates with CP risk factors and fetuses with CP risk factors（P0.01）.Conclusions IL-10 may be involved in the occurrence and development of CP;IL-10 can be used as an independent biological parameter of acute stress;IL-10 level can reflect the extent of brain injury,which there is an important clinical significance to the prevention and treatment of CP.

关 键 词：脑性瘫痪 白细胞介素-10 免疫-神经-内分泌网络 

分 类 号：R742.3[医药卫生—神经病学与精神病学]