陕西关中女性原发性骨质疏松患者Ⅰ型胶原基因多态性研究  

The research of collagen IA1 gene polymorphism in osteoporosis women patients of Shaanxi Guanzhong area

作　　者：韩燕[1] 王金堂[2] 王宇飞[2] 孙健[1,3] 

机构地区：[1]西安交通大学医学院遗传学与分子生物学系,西安710049 [2]西安交通大学医学院第一附属医院骨科 [3]西安交通大学环境与疾病相关基因教育部重点实验室

出　　处：《中国骨质疏松杂志》2010年第6期397-400,共4页Chinese Journal of Osteoporosis

基　　金：中国科学院"西部之光"人才培养计划([2009]236);陕西省科技计划项目(2002K10-G5省卫生厅)

摘　　要：目的从分子流行病学角度探讨陕西关中地区人群Ⅰ型胶原α1基因SPl位点多态性与原发性骨质疏松症、骨质疏松性骨折的相关性。方法选取陕西关中地区无血缘关系汉族绝经后骨质疏松患者83例及健康女性98例,生物化学方法检测剔除任何其他影响骨代谢因素后,骨密度仪检测腰椎、股骨BMD,及限制性片段长度多态性(RFLP)方法检测其CoLⅠA1SPl位点多态性。结果所研究181例样本CoLⅠA1基因SP1位点均为SS,所选样本未发现CoLⅠA1基因SP1位点多态性存在。结论陕西关中地区原发性骨质疏松女性患者与CoLⅠA1基因SPl位点多态性无相关性。Objective From molecular epidemiology suggest the relativities about the collagen Ⅰ A1 （CoL Ⅰ Al ） genes polymorphism between primay osteoporosis and osteoporotic fracture in Shaanxi Guanzhong area people as possibly implicated in reduced bone mineral density （ BMD）. Tbrough researching osteoporosis from molecular level, to elucidate the genetic basis of osteoporosis and provide theoretical base for preventing, diagnosing and treating osteoporosis. Methods Selecting the eighty-three Han post-menopausal women patients who were not related and ninety-eight health adult women from Shaanxi Guanzhong area, measure BMD of lumbar and thighbone by Bone Sonometers, and array the polymorphism of CoL [ A1 SP[ through the method of RFLP. Results ALL the people of CoL l A1 genotype is the ＂SS＂ type, And the people of ＂s＂ type was not found in the people of CoL I A1 genotype. Coaelusion In Shaanxi Guanzhong area,original, the polymorphism of CoL I A1 SPI in original osteoporosis woman patients is not related with osteoporosis.

关 键 词：Ⅰ型胶原蛋白 基因多态性 骨质疏松 

分 类 号：R363.1[医药卫生—病理学]