手术对非小细胞肺癌患者血清中血管内皮生长因子受体2和内皮抑素水平的影响  

Effects of operation on serum levels of vascular endothelial growth factor receptor 2 and endostatin in patients with non-small cell lung cancer

作　　者：杨异[1] 高宗礼[1] 赵天成[1] 吴伟铭[1] 赵永红[1] 何伟伟[1] 林海平[1] 

机构地区：[1]上海交通大学附属第六人民医院心胸外科,上海200233

出　　处：《肿瘤》2010年第6期535-538,共4页Tumor

基　　金：上海市卫生局科研基金资助项目(编号:2009088)

摘　　要：目的:探讨手术对非小细胞肺癌患者血清中血管内皮生长因子受体2(vascular endothelial growth factorreceptor 2,VEGFR2)和内皮抑素(endostatin,ES)水平的影响及临床意义。方法:通过对2009年1月1日—12月31日在上海交通大学附属第六人民医院心胸外科接受手术治疗的38例非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的血清VEGFR2和ES水平进行ELISA法检测,分析其变化、临床特征及意义。结果:手术前后ES水平分别为9.82(9.51,10.13)ng/mL和9.47(9.08,9.86)ng/mL,差异有统计学意义(P=0.000);手术前后VEGFR2水平分别为8.78(8.28,9.28)ng/mL和8.93(8.41,9.45)ng/mL,差异有统计学意义(P=0.034)。手术前ES水平与VEGFR2水平无明显相关性(P>0.05),手术后ES水平与VEGFR2水平呈显著正相关(r=0.351,P=0.031)。手术前后ES表达水平变化值除了与患者年龄呈明显正相关(r=0.029,P<0.05)外,与患者性别、吸烟指数、病理类型、肿瘤最大直径和临床分期均无明显相关性(P>0.05)。手术前后VEGFR2水平变化值与患者的吸烟指数、年龄、性别、病理类型、肿瘤最大直径和临床分期均无明显相关性(P>0.05)。结论:手术可导致NSCLC患者ES水平下降,VEGFR2水平升高,这可能是引起术后发生早期转移的原因之一,提示有必要在围手术期应用血管抑制剂ES。Objective：To study the influence and clinical significance of operation on serum levels of vascular endothelial growth factor receptor 2 （VEGFR2） and endostatin （ES） in patients with non-small cell lung cancer （NSCLC）.Methods：The serum levels of VEGFR2 and ES were detected by using ELISA method in 38 patients with NSCLC who have received surgery in the Department of Cardiothoracic Surgery of Shanghai Sixth People’s Hospital from January 1st 2009 to December 31st 2009. Their changes and clinical features and significance were analyzed.Results：The serum levels of ES were 9.82 （9.51, 10.13） ng/mL and 9.47 （9.08, 9.86） ng/mL before and after operation, respectively, which was slightly decreased after operation. The difference was significant （P=0.000）. The serum levels of VEGFR2 were 8.78 （8.28, 9.28） ng/mL and 8.93 （8.41, 9.45） ng/mL, respectively, before and after operation, respectively, which had slight increase. The difference was not significant （P=0.034）. The preoperative serum levels of ES did not correlate with that of VEGFR2（P〈0.05）. But the postoperative serum levels of ES had significantly positive correlation with that of VEGFR2 （r=0.351, P=0.031）. The serum levels of ES and VEGFR2, and their changes after operation, had no correlation with gender, pathological classification, maximum diameter of tumor body, and clinical stage of NSCLC （P〉0.05）.Conclusion：The postoperative serum level of ES was decreased and that of VEGFR2 was increased, which could explain the postoperative early metastasis of NSCLC. It suggests that ES should be used in the perioperative period to suppress the early metastasis.

关 键 词：癌 非小细胞肺 外科手术 受体 血管内皮生长因子 内皮抑素类 

分 类 号：R734.2[医药卫生—肿瘤]