Hsp90抑制剂的研究进展  

Advances in Heat Shock Protein 90 Inhibitors

作　　者：何彩梅[1] 李海燕[1] 魏大巧[1] 葛若梅[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650224

出　　处：《生物技术通报》2010年第7期64-67,共4页Biotechnology Bulletin

基　　金：昆明理工大学人才培养基金项目(KKZ0200726028)

摘　　要：热激蛋白90(heat shock protein90,Hsp90)作为分子伴侣在调节细胞生长、分化、凋亡等方面发挥着重要的作用。Hsp90抑制剂能与Hsp90结合,使其功能丧失,造成细胞的多种生理活动缺陷,在Hsp90功能研究和癌症治疗方面具有潜在的价值。综述了不同来源的Hsp90抑制剂及其作用机制,同时对新型Hsp90抑制剂的来源进行了探讨。Heat shock protein 90 is a kind of protein which plays very important roles in maintaining transformation and regulating the function of proteins involved in apoptotic, survival and growth pathways as molecular chaperones. The binding of Hsp90 inhibitors to Hsp90 may trigger Hsp90 function loss,cause cells physiological activities defects,they have potential value in Hsp90 function study and cancer therapy. The paper summarized the different sources of Hsp90 inhibitor and its mechanism of action.

关 键 词：HSP90 HSP90抑制剂 格尔德霉素根赤壳菌素 

分 类 号：Q51[生物学—生物化学]