胃动方Ⅰ对功能性消化不良大鼠胃肠动力的影响及作用机制  

Experimental study of WeidongfangⅠon gastric motility of rat with functional dyspepsia

作　　者：梁国强[1] 张露蓉[1] 江国荣[1] 任光荣[2] 

机构地区：[1]江苏省苏州市中医医院中医药研究所,江苏苏州215000 [2]江苏省苏州市中医医院消化科,江苏苏州215000

出　　处：《河北中医》2010年第4期601-602,605,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：江苏省中医药管理局基金项目(编号:H05092)

摘　　要：目的探讨胃动方Ⅰ对胃肠动力的影响及其作用机制。方法将60只SD大鼠随机分为空白对照组、模型组及西沙必利组,胃动方Ⅰ大、中、小剂量组,每组10只。除空白对照组外,其余各组采用甘草溶液灌胃复制胃肠动力障碍大鼠模型。造模成功后第2d,空白对照组、模型组大鼠予蒸馏水,容量按10mL/kg灌胃,每日1次,连续3d;胃动方Ⅰ大、中、小剂量组分别按生药10.8、3.6、1.2mg/kg,容量按10mL/kg灌胃,每日1次,连续3d;西沙必利组按剂量1.4mg/kg,容积按10mL/kg灌胃,每日1次,连续3d。观察各组大鼠胃排空率、小肠推进率以及胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)的变化。结果胃动方Ⅰ组胃排空率、小肠推进率以及MTL、GAS、VIP含量与模型组及西沙必利组比较差异均有统计学意义(P<0.05),胃动方Ⅰ大、中剂量组胃排空率、小肠推进率以及MTL、GAS升高,VIP含量降低。胃动方Ⅰ小剂量组小肠推进率与模型组比较差异无统计学意义(P>0.05)。结论胃动方Ⅰ具有胃肠激素良性改善作用,其对胃肠动力的促进作用,可能与其可提高胃排空率及MTL、GAS水平,降低VIP水平有关。胃动方Ⅰ与小肠推动率存在相关性,且呈明显量效关系。Objective To study the effects of WeidongfangⅠ on the gastrointestinal motility.Methods 60 rats were randomly control group,model group,Cisapride group,low-dose Weidongfang,middle-dose Weidongfang and high-dose Weidongfang groups.The animal model of gastrointestinal motility disorder in rats was established by licorice root decoction（LRD）.Intragastric administration of distilled water（10 mL/kg）,Cisapride（1.4 mg/kg）,and low,middle-and high-dose Weidongfang（1.2 g/kg,3.6 g/kg and 10.8 g/kg）were carried on each group,respectively.Gastric emptying rate,intestinal propulsive rate,MTL,Gas and VIP in blood of rats were measured for effect of evaluation.Results There were significant differences between Weidongfang groups,model group and group on gastric emptying rate,intestinal propulsive rate,MTL,Gas and VIP in blood.Gastric emptying rate,intestinal propulsive rate,MTL and Gas were increased,and VIP was decreased in middle-dose Weidongfang and high-dose Weidongfang groups.Conclusion WeidongfangⅠimprove motility function of intestinal of animal model by increasing the content of MTL,Gas,and decreasing that of VIP in blood of the models.

关 键 词：消化不良 促胃动素 胃泌素类 血管活性肠肽 大鼠 

分 类 号：R570.5[医药卫生—消化系统] R347.92[医药卫生—内科学]