酵母金属硫蛋白对酵母和小鼠抗γ射线损伤的作用  

EFFECT OF SACCHAROMYCES CEREVISIAE BD101 Cu-MT ON RESISTING IRRADIATION DAMAGE IN YEAST AND MICE

作　　者：贾乐[1] 王龙[1] 林稚兰[1] 薛宏伟[2] 魏雪涛[2] 林慰慈[2] 

机构地区：[1]北京大学生命科学学院,北京100871 [2]北京医科大学公共卫生学院,北京100083

出　　处：《菌物系统》1999年第1期44-48,共5页Mycosystema

基　　金：国家自然科学基金!39370021

摘　　要：酿酒酵母BD101菌株的金属硫蛋白能清除羟基自由基。含金属硫蛋白的酵母菌有拮抗60Coγ射线的作用。用计数血液中血小板（PLT）、白细胞（WBC）变化来研究酵母Cu－MT在小鼠γ射线损伤中的作用。结果表明，该菌Cu－MT对PLT降低的改善和回升有作用。但未观察到其对WBC总数变化的影响。提示酿酒酵母Cu－MT在临床放射病治疗和放疗后抗出血方面有良好的应用前景。The Cu-metallothionein of Saccharomyces cerevisiae BD101 can scavenge hydroxyl radicals. The yeast cells containing Cu-MT can protect against 60Coγray irradiation damage. The effects of S. cerevisiae BD101 Cu-MT on resisting irradiation damage in 60Coγ ray irradiation mice were studied by counting the changes of platelet (PLT) and white blood corpuscle (WBC). It was demonstrated that the BD101 Cu-MT could reduce the decrease in the number of PLT and promote it to rise back, but it has not been observed that this Cu-metallothionein could affect positively the change of the number of WBC. It suggests that there is a promising prospect for applying S.cerevisiae BD101 Cu-metallotionein to clinical irradiation sickness and to resistance of shedding blood after irradiation therapy.

关 键 词：酿酒酵母 金属硫蛋白 γ射线损伤 血小板 

分 类 号：Q949.326.1[生物学—植物学]