胆固醇合成途径的关键酶:HMG辅酶A还原酶和疾病  

The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease

作　　者：汪维[1] 童坦君[1] 

机构地区：[1]北京医科大学生物化学与分子生物学系

出　　处：《生理科学进展》1999年第1期5-9,共5页Progress in Physiological Sciences

摘　　要：在真核生物中，３羟基３甲基戊二酸单酰辅酶Ａ还原酶是催化合成胆固醇和非甾醇类异戊二烯的共同前体———甲羟戊酸的关键酶。该酶的活性在转录、转录后、翻译及酶降解等多个水平上受到调节。胆固醇在动脉粥样硬化的发生、发展中起重要作用，而异戊二烯则参与细胞增殖调节、信号转导及肿瘤发生过程。目前，该酶已成为一些有效的抗动脉粥样硬化药物治疗的靶点。In eukaryotes, 3 hydroxy 3 methylglutaryl coenzyme A (HMG CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non sterol isoprenoids,mevalonate. The regulation of the enzyme activity occurs at the transcription, post transcription, translation and protein degradation levels. Cholesterol contributes to the generation and development of atherosclerosis while non sterol isoprenoids play a role in regulation of cell proliferation, signal transduction and generation of cancers.At present,the enzyme is the target of several drugs effective against atherosclerosis.

关 键 词：胆固醇合成 代谢调节 HMG-COA 心血管疾病 

分 类 号：Q591.5[生物学—生物化学] R541.4[医药卫生—心血管疾病]