透明质酸、层粘连蛋白、Ⅲ型前胶原和Ⅳ型胶原血清学指标对肝硬化诊断的价值  

Diagnostic value of detection of serum HA、LN、PCⅢ、CⅣ for liver fibrosis

作　　者：薛永杰[1] 杨国嵘[1] 张文杰 贺雪姣[1] 

机构地区：[1]中国人民解放军第一医院病理科,甘肃兰州730030 [2]甘肃省第二人民医院感染科

出　　处：《中西医结合肝病杂志》2010年第3期178-179,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:评价血清纤维化指标对于诊断肝硬化的应用价值。方法:52例经肝穿刺确诊为慢性乙型肝炎及肝硬化患者,应用放射免疫法检测血清HA(透明质酸)、LN(层粘连蛋白)、PCⅢ(Ⅲ型前胶原)、CⅣ(Ⅳ型胶原)水平。结果:肝脏病理炎症及纤维化分级与血清HA、LN、PCⅢ、CⅣ水平有显著相关性,组间对比部分有统计学意义,炎症分级组较为明显。结论:检测血清HA、LN、PCⅢ、CⅣ水平对于判断肝脏炎症及纤维化程度有一定价值和意义。Objective：To explore the application value of detection of serum HA、LN、PCⅢ、CⅣ for liver fibrosis.Methods：Fibrosis-degree of 52 case were confirmed by liver biopsy.Levels of serum HA、LN、PCⅢ、CⅣ were measured with radioimmunoassay.Results：The serological indexes were in accordance with the pathological inflammation-grade and fibrosis-stage of liver biopsy tissues.There were significant correlation between the degree of inflammation or fibrosis and the pathological inflammation-grade.The difference of HA、LN、PCⅢ、CⅣ were partly obvious between groups ,especially with the pathological inflammation-grade.Conclusion：The detection of four markers are useful and value to help the diagnosis of liver fibrosis-grade and inflammation-grade.

关 键 词：肝纤维化 透明质酸 层粘连蛋白 Ⅲ型前胶原 Ⅳ型胶原 

分 类 号：R575.2[医药卫生—消化系统]