乳腺癌分子靶向治疗的新进展  

New progress of molecular targeted therapy for breast cancer

作　　者：潘峰[1] 潘跃银[1] 

机构地区：[1]安徽医科大学第一附属医院肿瘤科,安徽合肥230022

出　　处：《中华疾病控制杂志》2010年第6期566-569,共4页Chinese Journal of Disease Control & Prevention

基　　金：安徽省科技厅重点项目(07020304102)

摘　　要：乳腺癌的靶向治疗研究已经成为乳腺癌治疗领域研究的热点,是继手术、放疗和化疗三大传统模式之后一种全新的生物治疗模式。分子靶向治疗是针对可能导致细胞癌变的靶点,如原癌基因和抑癌基因、细胞信号转导通路、细胞因子及受体、抗肿瘤血管形成等,从分子水平逆转这种恶性生物学行为,从而抑制肿瘤细胞生长,具有特异度高、副作用小的优点。本文主要对乳腺癌分子靶向治疗药物作用的靶点及靶向治疗的最新进展做一综述。Currently targeted therapy of breast cancer therapy has become the hot research field and a kind of brand-new biological treatment mode after three traditional pattern of the surgery, radiotherapy and chemotherapy for breast cancer. Molecular targeted therapy is aimed at the target that may cause cancer cells, such as protocarcinogenic genes and tumor-suppressor genes, cell signaling pathways, cytokines and receptors, antiangiogenesis etc. It can reverse malignant biology behavior to inhibit tumor cell growth from the molecular level and has the advantages of high specific effects and low side effects. This paper focuses on the drug of the molecular targeted therapy for breast cancer and the latest progress of targeted therapy.

关 键 词：乳腺肿瘤 靶向治疗 进展 

分 类 号：R737.9[医药卫生—肿瘤]