乳腺癌LewisY抗原的表达及临床病理意义探讨  

Expression of Lewis Y antigen in human breast carcinoma

作　　者：王莉芬[1,2] 贺斌[1,2] 朱正美[1,2] 

机构地区：[1]大连医科大学第二临床学院病理科 [2]大连医科大学生化学教研室

出　　处：《大连医科大学学报》1999年第1期17-20,共4页Journal of Dalian Medical University

摘　　要：观察了ＬｅｗｉｓＹ（Ｌｅｙ）抗原与乳腺癌细胞增殖和转移的关系。用ＳＰ免疫组化法，检测了２３例乳腺癌原发癌和腋窝淋巴结转移癌组织中Ｌｅｙ在癌细胞内的表达情况。并用ＡｇＮＯＲｓ染色法观察癌细胞增殖活性，从而分析了癌细胞Ｌｅｙ抗原表达与增殖活性之间的关系。结果２２／２３例原发灶和１７／１８例转移灶中癌细胞内有Ｌｅｙ表达。随着癌细胞Ｌｅｙ表达强度的增加，其ＡｇＮＯＲｓ数量增多，并且腋窝淋巴结癌转移的数量也呈增高趋势。结论：Ｌｅｙ抗原的表达与乳腺癌细胞增殖活性和腋窝淋巴结转移情况密切相关，Ｌｅｙ抗原可作为判断乳腺癌预后的参考指标之一。To investigate the relationship between Le y antigen expression and the proliferative activity of human primary breast carcinoma and its metastasis,23 cases of primary breast cancer inclyding metastatic 18 axially lymph nodes were studied retrospectively.Immunohistochemical SP method was used to examine Le y antigen expression in the cancer tissue.The proliferative activity of the carcinoma was deteoted by AgNORs staining.The relationship between Le y antigen expression and the proliferative activity of the same cancer tissue was analyzed.Results:The Le y antigen expression was detected in 22/23 of primary carcinoma tissues and 17/18 cases of axially lymph node metastatic lesions.As the intensity of Le y expression strengthened the AgNORs counts and the lymph node metastatic rate were increasing.These results suggested that Le y antigen expression correlated closely to the proliferative activity and the lymph node metastasis in breast carcinoma.The expression of Le y antigen may be served as one of the reference parameters of predicting the prognosis human breast cancer.

关 键 词：LewisY抗原 核仁组成区 肿瘤转移 乳腺癌 

分 类 号：R737.903[医药卫生—肿瘤] R73－37[医药卫生—临床医学]