急性脑梗塞患者IL-6、IL-8和TNF-α的测定及临床意义  

Clinical significance of serum interleukin-6、interleukin-8 and tumor Necrosis factor-α in patients with acute cerebral infarction

作　　者：吴映曼[1] 蔡毅[1] 

机构地区：[1]海南省农垦总局医院神经内科,海南海口570226

出　　处：《中国热带医学》2010年第8期997-998,共2页China Tropical Medicine

摘　　要：目的探讨急性脑梗塞患者血浆白细胞介素6(IL-6)、白细胞介素8(IL-8)及肿瘤坏死因子-α(TNF-α)在发病中的作用及临床意义。方法采用放射免疫分析法检测46例急性脑梗塞患者血浆IL-6、IL-8和TNF-α含量,并与34例正常对照组比较。结果急性脑梗塞患者急性期血浆IL-6、IL-8和TNF-α水平显著高于正常对照组(P<0.01),恢复期3种因子有下降的趋势,但仍高于正常对照组(P<0.01),急性脑梗塞患者恢复期IL-6、IL-8和TNF-α水平低于急性期(P<0.05)。结论脑梗塞发病过程中存在IL-6、IL-8和TNF-α介导的炎症和免疫反应,IL-6、IL-8和TNF-α的测定对急性脑梗塞的治疗和预后判断有一定价值。Aim To investigate the role of interleukin-6（IL-6）interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）in patients with acute cerebral infarction,and its clinical significance. Methods The concentration of serum IL-6、IL-8 and TNF-α were measured by radioimmunoassay in 46 patients with acute cerebral infarction,and the results were compared with those in 34 healthy contro1. Results The serum IL-6、IL-8 and TNF-α levels in patients were significantly higher in acute patients with cerebral infarction than that of control group（P0.01）. then serum of IL-6、IL-8 and TNF-α decreased .but they were still higher than norma1（P0.01）.The serum IL-6、IL-8 and TNF-α levels in patients were significantly low in convalescent patients with cerebral infarction than that of acute patients with cerebral infarction （P 0.05）. Conclusion There are some inflammatory and immunological response mediated by IL-6、IL-8 and TNF-α in the pathogenesis of cerebral infarction. The determination of serum IL-6、IL-8 and TNF-α levels could be prognostic to the development and treatment of cerebral infarction.

关 键 词：脑梗塞 白细胞介素6 白细胞介素8 肿瘤坏死因子-Α 

分 类 号：R743.33[医药卫生—神经病学与精神病学]