卡拉胶寡糖的制备及其生物活性的研究  

Preparation of Carrageenan Oligosaccharides and Study on Its Biological Activity

作　　者：吴海歌[1] 王艳预[1] 姚子昂[1] 

机构地区：[1]大连大学生物工程学院辽宁省生物有机化学重点实验室,辽宁大连116622

出　　处：《化学与生物工程》2010年第6期37-40,共4页Chemistry & Bioengineering

基　　金：国家自然科学基金资助项目(30901875);辽宁省教育厅科技资助项目(2008050)

摘　　要：对卡拉胶的降解条件、降解获得的卡拉胶寡糖的理化性质及其抗肿瘤活性进行了研究。结果表明,60℃下用0.5%硫酸降解1%的卡拉胶,可以得到比较均匀、分子量大小不等的多种卡拉胶寡糖。用这种方法获得的卡拉胶寡糖对结肠癌细胞DLD1生长的抑制作用远远强于相同浓度的卡拉胶,为拓宽卡拉胶的应用提供了实验依据。The degradation condition for carrageenan,the physico-chemical property and anticancer activity of carrageenan oligosaccharides（CGOS） obtained were studied.The results showed that when 1% carrageenan was degraded with 0.5% sulphuric acid at 60℃,the products were uniform and the CGOS were inequality of size.The inhibition rate of colon carcinoma cell DLD1 by CGOS was much higher than that by carrageenan.It provides experimental reference to widen the application of carrageenan.

关 键 词：卡拉胶 卡拉胶寡糖 降解 生物活性 

分 类 号：Q533[生物学—生物化学]