慢性阻塞性肺疾病和慢性中重度牙周炎患者血清白细胞介素19的表达分析  

Expression and analysis of serum interleukin-19 in patients with chronic obstructive pulmonary disease and periodontitis

作　　者：林梅[1] 林婷[1] 张菁[1] 李一梓[1] 张良琼[1] 庞宝森[2] 王左敏[1] 

机构地区：[1]首都医科大学附属北京朝阳医院口腔科,100020 [2]首都医科大学附属北京朝阳医院北京市呼吸病研究所

出　　处：《中国医药》2010年第7期588-590,共3页China Medicine

基　　金：基金项目：国家自然科学基金资助项目（30872878）

摘　　要：目的 通过比较慢性阻塞性肺疾病（COPD）患者、慢性中重度牙周炎患者和COPD合并中重度慢性牙周炎患者血清中白细胞介素19（IL-19）的含量,探讨中重度慢性牙周炎和COPD之间可能存在的关系.方法 选取临床确诊的COPD患者51例,中重度慢性牙周炎患者61例,COPD合并中重度慢性牙周炎患者97例,健康成人22名共计4组.收集各组受试者静脉血清样本,采用酶联免疫吸附法测定血清IL-19水平.结果 慢性中重度牙周炎患者血清IL-19含量（106.31±32.45）ng/L与非牙周炎患者血清IL-19（95.54±39.21）ng/L含量差异有统计学意义（P＜0.05）,COPD患者血清IL-19含量（107.41±38.43）ng/L与非COPD患者（94.48±33.23）ng/L差异也有统计学意义（P＜0.05）,但析因设计方差分析发现在慢性牙周炎与COPD之间的交互作用P＞0.05,即不能认为两者之间存在交互影响.结论 血清中IL-19的表达可能与COPD及中重度慢性牙周炎发病机制有关.Objective Periodontitis is an inflammatory disease which may be associated with chronic obstructive pulmonary disease （COPD）. Interleukin-19 （IL-19） might be involved in the common inflammatory mechanisms. This study investigated the association of serum levels of IL-19 with periodontitis and COPD in a Chinese population. Methods Fifty-one patients with chronic obstructive pulmonary disease, sixty-one patients with periodontitis, ninety-seven patients with both COPD and periodontitis and twenty-two healthy people were included in the study. The blood serum IL-19 levels was detected by ABC-ELISA. Results The differences in IL-19 expression were significant both between periodontitis group and non-periodontitis group, COPD group and non-COPD group （P 〈 0.05）. However, there was no interaction detected between the two diseases on IL-19 expression. Conclusion Serum IL-19 level increases in both periodontitis patients and COPD patientsand IL-19 might be associated with the pathogenesis of periodontitis and COPD.

关 键 词：牙周炎 肺疾病 慢性阻塞性 血清 白细胞介素-19 

分 类 号：R781.4[医药卫生—口腔医学]