长期局部用抗青光眼药物对眼表结构及感觉的影响  

Influence of long-term use of anti-glaucoma medicine on ocular surface structures and sensation

作　　者：辛晨[1] 王宁利[2] 

机构地区：[1]首都医科大学附属北京安贞医院眼科,100029 [2]首都医科大学附属北京同仁医院眼科中心

出　　处：《中国医药》2010年第7期669-671,共3页China Medicine

摘　　要：目的 探讨长期局部应用抗青光眼药物对眼表结构及感觉的影响.方法 对92例长期局部使用抗青光眼药物的患者和50例白内障患者,进行角结膜荧光素染色、虎红染色、泪膜破裂时间（BUT）、泪液分泌试验泪膜脂质层评价.结果 青光眼患者眼部存在明显的干涩感（P=0.025）、异物感（P=0.032）和烧灼感（P=0.028）,眼部不适感评分（P=0.041）也显著增高,同时荧光素染色（P=0.031）和虎红染色（P=0.024）、泪膜脂质层（P=0.048）均显著高于白内障组,而Schirmer Ⅰ试验值（P=0.045）和BUT值（P=0.043）则显著低于白内障组.而用药种类较多的B亚组青光眼患者眼部异物感（P=0.040）、烧灼感（P=0.013）和咽部不适感总体评分（P=0.039）更为明显,荧光素染色（P=0.022）和虎红染色（P=0.035）均显著高于用药较少的A亚组,并且Schirmer Ⅰ试验值（P=0.038）和BUT值（P=0.045）则显著低于用药较少组.用药时间较长的D亚组青光眼患者相较用药时间较短的C亚组患者眼部干涩感（P=0.043）、异物感（P=0.038）、畏光感（P=0.049）、烧灼感（P=0.026）及眼部不适感评分（P=0.041）均显著增高,而荧光素染色（P=0.021）和虎红染色（P=0.039）均显著升高,SchirmerⅠ试验值（P=0.021）及BUT（P=0.042）均显著减小.结论 长期使用抗青光眼药物可破坏眼表结构,引起患眼明显的不适症状,且药种类的增加及用药时间的延长会加剧这种损害.Objective To detect the influence of long-term use of anti-glaucoma medicine on the ocular surface structures and sensation. Methods The ocular surface structures and sensation between the glaucoma with medicine group and the cataract group, between the groups in which the patients received the medicine for different period of time, and also between the groups in which the patients received different amount of medicine were compared. Results The positive rate of dryness, foreign body sensation and photophobia in patients with anti-glaucoma medicine was much higher than the group with cataract. And scores for comfortlessness and ocular surface dyeing dramatically increased in the group with anti-glaucoma medicine. The value of Schirmer test and BUT dramatically decreased in this group. Conclusions Long-term use of anti-glaucoma medicine destroys the ocular surface structures and comfort. Furthermore this damage would deteriorate with the prolongation and variety of medicine use.

关 键 词：青光眼 眼表结构 眼部感觉 

分 类 号：R775[医药卫生—眼科]