大鼠增生性糖尿病视网膜病变的血流动力学评价  

Evaluation on the changes of retinal hemodynamics in of proproliferative diabetic retinopathy rats

作　　者：陈瑛[1] 张康兰[2] 刘兰芬[3] 丁吉元[4] 

机构地区：[1]济南军区青岛第一疗养院特检科,山东青岛266071 [2]济南军区总医院眼科,山东济南250031 [3]济南军区总医院超声科,山东济南250031 [4]济南军区总医院病理科,山东济南250031

出　　处：《实用医药杂志》2010年第6期548-550,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨增生性糖尿病视网膜病变(PDR)的血流动力学变化特点。方法 48只Wistar大鼠,其中对照组(15只)、非增生性糖尿病视网膜病变组(NPDR组,21只)、增生性糖尿病视网膜病变组(PDR组,12只);结合视网膜消化铺片,利用CDFI研究其视网膜血流动力学特点。结果在PDR组,CRA的平均流速(MV)减低显著,搏动指数(PI)增高明显,视网膜中央静脉(CRV)内径增宽;与NPDR组、对照组比较差异显著(P<0.05)。结论增生性糖尿病视网膜病变的血流动力学呈现特征性改变。Objective To study the hemodynamics features of the central retinal artery（CRA） and CRV in proproliferative diabetic retinopathy （PDR） rats. Method The total of 48 rats were divided to three groups： control group（15）, NPDR （non-PDR） group（21） and PDR group（15）. The retinal hymodynamics with color Doppler flow imaging （CDFI） were observed by combining with retinal digest preparations. Result Mean velocity （MV） of CRA was reduced, and pulsatility index （PI） of CRA was increased, the diameter of central retinal veih （Dcrv） was broderned in PDR group rats. Conclusion It is obvious that hymodynamics of PDR rats has changed specifically.

关 键 词：糖尿病视网膜病变 超声检查 多普勒超声 彩色 

分 类 号：R774.1[医药卫生—眼科] R587.1[医药卫生—临床医学]