白假丝酵母菌与婴幼儿龋相关性的初步探讨  

Relationship between Candida albicans and early childhood caries

作　　者：邱荣敏[1] 赵玮[1] 林艳[1] 高硕[1] 罗伟[1] 卢佳璇[1] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院.口腔医学研究所,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2010年第3期47-49,共3页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：广东省科技计划社会发展项目(00316971120302088)

摘　　要：目的初步探讨白假丝酵母菌与婴幼儿龋(ECC)的相关性。方法采用分层整群抽样的方式随机选择广州市区及城郊447名3～5岁健康儿童作为研究对象,将其分为ECC组(n=238)和无龋组(n=209)。采集龋坏组织样本及无龋牙的龈上菌斑共363份,应用科玛嘉培养基、芽管试验进行检测、鉴定,并运用卡方检验对比分析ECC组与无龋组、市区和城郊组间白假丝酵母菌检出情况;建立Logistic回归方程分析患龋情况与白假丝酵母菌检出率的相关性。结果 ECC组和无龋组中白假丝酵母菌检出率分别为44.1%和19.2%(χ2=22.213,P<0.001)。ECC组中,患龋率高的城郊组白假丝酵母菌检出率(79.7%)高于市区组(28.0%)(χ2=55.242,P<0.001)。经Logistic回归分析,龋失补牙面数每增加2.129个,白假丝酵母菌检出机率会相应增加0.104(P<0.001)。结论白假丝酵母菌与婴幼儿龋的发生密切相关,可能为婴幼儿龋发生过程中的重要致龋菌之一。Objective To explore the relationship between Candida albicans and early childhood caries（ECC） by detecting Candida albicans from dental caries of children with ECC and supragingival plaque of children without caries,and comparing the differences of the frequency of Candida albicans in urban and suburban areas in Guangzhou.Methods 447 healthy children（aged 3-5 years） were divided into two groups：238 children in the ECC group and 209 children in the caries-free group.A total of 363 samples collected from dental caries and supragingival plaque were cultured on CHROMagar Candida,and all the isolates were identified by germ tubes test.The χ2 test was used to analyze the relationship between the isolation frequency of Candida albicans and dental caries.The Logistic regression was applied to analyze the association between dmft and the isolation frequency of Candida albicans.Results The frequency of Candida albicans isolated from ECC group was higher than that of the non-caries group（44.1% vs 19.2%,χ2= 22.213,P 0.001）,and it was higher in suburban areas than that in urban areas（79.7% vs 28.0%,χ2=55.242,P 0.001） in the ECC group.The detection rate of Candida albicans increased 0.104 as dmft increased 2.129.（by Logistic regression analysis,P 0.001）.Conclusions There is a significant association between the presence of Candida albicans and ECC.Candida albicans may be one of the important cariogenic microorganisms in ECC.

关 键 词：白假丝酵母菌 婴幼儿龋 龋失补牙面数 

分 类 号：R788.1[医药卫生—口腔医学]