胶质瘤的端粒酶研究进展  

Research Development of Telomerase for Glioma

作　　者：黄金[1] 张胜平[1] 邓兴力[1] 杨智勇[1] 

机构地区：[1]昆明医学院第一附属医院神经外科,昆明650000

出　　处：《医学综述》2010年第13期1929-1931,共3页Medical Recapitulate

基　　金：云南省应用基础研究计划(2007C244M)

摘　　要：端粒、端粒酶的研究是分子细胞生物学以及医学的热点之一。端粒酶的生物活性机制被认为是细胞获得永生化的必要途径,是恶性转化的基础,与细胞的衰老、肿瘤发生密切相关。随着对端粒酶的结构及其在正常和肿瘤组织细胞的调控机制的理解和认识,靶向端粒酶的胶质瘤治疗将是今后研究的重点。现就近几年反义寡核苷酸、RNA干扰、核酸、基因方面、反转录酶抑制剂等对端粒酶的作用影响予以综述。The research of telomere and telomerase is one of the hotspots in molecular cell biology and medicine. Mechanisms for the biological activity of telomerase is considered as the necessary means of immortalized cells and the base for malignant transformation,closely related to cell aging and cancer. With the understanding and awareness of the telomerase structure and the regulating mechanism of telomerase in normal and tumor tissue,telomerase-targeted gliomas therapies will be the focus of future research. This paper reviews the roles of antisense oligonucleotide,RNA interference,nucleic acids, genes,and reverse transcriptase inhibitors in telomerase.

关 键 词：端粒 端粒酶 胶质瘤 靶向治疗 

分 类 号：R739.4[医药卫生—肿瘤]