MMP-9和Actin在胃肠道间质瘤中的表达及意义  

The Expression of MMP-9 and Actin in Gastrointestinal Stromal Tumor

作　　者：程玲[1] 郑美蓉[1] 龚勇[2] 吴萍[2] 

机构地区：[1]九江学院基础医学院 [2]九江学院医学科研中心,江西九江332000

出　　处：《九江学院学报（自然科学版）》2010年第2期53-55,共3页Journal of Jiujiang University：Natural Science Edition

摘　　要：目的:探讨MMP-9和Actin在胃肠道间质瘤中的表达及其意义。方法:应用免疫组织化学技术检测胃肠道良性间质瘤、胃肠道恶性间质瘤和正常胃肠道组织中MMP-9和Actin的表达情况。结果:MMP-9和Actin在正常胃肠道组织和良性胃肠道间质瘤瘤细胞中呈阳性表达,而在恶性胃肠道间质瘤瘤细胞中呈阴性表达(p<0.05)。结论:瘤细胞MMP-9和Actin表达阴性可能对恶性胃肠道间质瘤有诊断参考价值。Objective To study the expression and significance of MMP - 9 and Aetin proteins in gastrointestinal stromal tumor. Methods The MMP -9 and Actin proteins were detected by immunohistochemistry in benign gastrointestinal stromal tumor , malignant gastrointestinal stromal tumor and normal gastrointestinal tissue. Results The positive expression of of MMP - 9 and Actin proteins was found in in benign gastrointestinal stromal tumor and normal gastrointestinal tissue, but negative expression in malignant gastrointestinal stromal tumor （ p 〈 0. 05 ）. Conclusions It may has reference significance to diagnosis malignant gastrointestinal stromal tumor with negative expression of MMP - 9 and Actin proteins in tumor cells.

关 键 词：胃肠道间质瘤 基质金属蛋白酶MMP-9 肌动蛋白Actin 免疫组化 

分 类 号：R730.262[医药卫生—肿瘤] R735[医药卫生—临床医学]