新型温敏性栓塞剂用于脑动静脉畸形实验研究  

A new-type non-adhesive thermosensitive liquid embolic agent for the embolization of cerebral arteriovenous malformation:an experimental study

作　　者：王绍胜[1] 张文堃[1] 董杰[1] 

机构地区：[1]济南山东大学附属千佛山医院影像科,250014

出　　处：《介入放射学杂志》2010年第6期471-474,共4页Journal of Interventional Radiology

摘　　要：目的合成一种新型温度敏感性液体栓塞材料并探讨其栓塞脑动静脉畸形(AVM)的可行性。方法应用氮-异丙基丙烯酰胺和氮-正丙基丙烯酰胺合成共聚物,进行物理性质测定和生物学检测并进行体外AVM模型栓塞试验。结果共聚物具有低临界溶解温度(LCST),具有水溶性和非黏附性特点,生物相容性好,能成功栓塞体外AVM模型。结论该共聚物为一种脑AVM血管内栓塞治疗的新型液体栓塞材料,可进一步用于临床实验研究。Objective To synthesize a new-type thermosensitive liquid embolic material and to investigate the feasibility of using this material to occlude cerebral arteriovenous malformations （AVMs）.Methods The copolymer was synthesized with N-isopropylacrylamide （NIPAM） and N-n-propylacrylamide （NNPAM）,and it＇s physical and biological properties were estimated.The embolization of AVMs model in vitro by using this copolymer was conducted and the results were analyzed.Results The new-type copolymer possessed unique thermal behavior of lower critical soluble temperature （LCST）,and it was water-soluble and non-adhesive with better biocompatibility.The successful embolization of AVMs model could be reliably obtained.Conclusion The copolymer synthesized by the authors is a new-type liquid embolic agent suitable for endovascular embolization of cerebral AVMs in vitro.Based on the results in experiment animals having been reported in medical literature,this copolymer can be further used in clinical research.

关 键 词：温度敏感性 栓塞剂 动静脉畸形 介入性 

分 类 号：R743.4[医药卫生—神经病学与精神病学]