3,4-二氯苯丙烯酰另丁胺抗脂质过氧化作用与对大鼠脑缺血的保护作用  

Antioxidation of 3,4 dichlorophenyl propenoyl sec butylamine and its protective effect on cerebral ischemia/reperfusion in rats

作　　者：王迪[1,2,3] 孙光春[1,2,3] 陶成[1,2,3] 李晓东[1,2,3] 赵艳杰 

机构地区：[1]锦州医学院药理教研室 [2]北京医科大学基础医学院药理学系 [3]锦州市中心医院麻醉科

出　　处：《中国药学杂志》1999年第1期20-22,共3页Chinese Pharmaceutical Journal

摘　　要：目的：研究３，４二氯苯丙烯酰另丁胺（简称ＡＥＤ８８０１）对大鼠脑缺血／再灌注损伤的作用及探讨其在抗脂质过氧化方面的影响。方法：建立Ｐｕｌｓｉｎｅｌｉ四血管阻断大鼠脑缺血／再灌注模型，通过生化检测手段，对脑组织中与脂质过氧化有关的一些指标进行检测。结果：ＡＥＤ８８０１能使脑缺血／再灌注大鼠脑组织中超氧化物歧化酶（ＳＯＤ）活性、谷胱甘肽过氧化物酶（ＳｅＧＳＨＰｘ）活性增加；脑组织及血清中丙二醛（ＭＤＡ）含量降低；脑组织中肌酸激酶（ＣＫ）、乳酸脱氢酶（ＬＤＨ）活性提高。结论：ＡＥＤ８８０１对脑缺血／再灌注损伤具有保护作用。OBJECTIVE:To study the protective effect of 3,4 dichlorophenyl propenoyl sec butylamine (AED 8801 ) on cerebral ischemia/reperfusion in rats and to investigate its protective mechanisms of antioxidation.METHODS:The model of cerebral ischemia/reperfusion in rats was established by the occlusion of four vessl to study the protective effect of AED 8801 .With biochemical methods,some indices relate to lipid peroxidation of brain tissue were measured. RESULTS:It was found that AED 8801 elevated the activity of SOD and Se GSH P x in brain tissue ofcerebral ischemia/reperfusion in rats,decreased MDA contents in brain tissue and serum,elevated the activity of LDH and CK in brain tissue,respectively. CONCLUSION: AED 8801 can protect the injury of cerebral ischemia/reperfusion. Its mechanism is due to the antioxidative function.

关 键 词：脑缺血 脂质过氧化 再灌注损伤 AED8801 大鼠 

分 类 号：R743.31[医药卫生—神经病学与精神病学]