ERK1/2磷酸化在鼻息肉组织中的表达及其意义  

Study of phosphorylated ERK1/2 on nasal polyps

作　　者：王天生[1] 初令[1] 陈江波[1] 陈玉[1] 刘更盛[1] 

机构地区：[1]中南大学湘雅三医院耳鼻咽喉头颈外科,长沙410013

出　　处：《临床耳鼻咽喉头颈外科杂志》2010年第11期492-495,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:研究磷酸化的细胞外信号调节激酶1/2(ERK1/2)在鼻息肉组织中的表达及其意义。方法:应用免疫组织化学研究磷酸化的ERK1/2在鼻息肉组织和正常中鼻甲黏膜的表达及定位。进一步用免疫印迹对磷酸化ERK1/2在鼻息肉组织的表达进行半定量分析。结果:免疫组织化学发现,磷酸化ERK1/2在鼻息肉表达显著高于正常对照组,主要定位于增生的上皮细胞、炎症细胞、腺上皮细胞和内皮细胞,且以胞核阳性为主。免疫印迹结果显示鼻息肉中磷酸化ERK1/2的表达显著高于正常中鼻甲黏膜,为其4.2倍。结论:研究提示磷酸化ERK1/2可能在鼻息肉的发生发展过程中起重要作用。Objective：To study the expression of phosphorylated extracelluar regulator kinase（ERK1/2） on nasal polyps.Method：The immunohistochemisty and Western-blot were used to study the phosphorylation of ERK1/2 on the normal nasal mucosa and nasal polyps.Result：The phosphorylated ERK1/2 was mainly expressed on the hyperplastic epithelium,inflammatory cells,glandular epithelium and endothelium of nasal polyps by immunohistochemistry,which was much stronger on nasal polyps than that of normal mucosa.The expression of phosphorylated ERK1/2 was 4.2 times than that of normal mucosa.Conclusion：The study indicated that the phosphorylation of ERK1/2 might play an important role on the occurrence and progression of nasal polyps.

关 键 词：鼻息肉 信号通路 

分 类 号：R730.21[医药卫生—肿瘤]