头颈部恶性淋巴瘤的临床特征及治疗  

Manifestations and management of malignant lymphoma in head and neck

作　　者：李清明 李湘平[2] 何英[2] 

机构地区：[1]深圳市第四人民医院耳鼻咽喉头颈外科,深圳518033 [2]南方医科大学南方医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2010年第12期551-553,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨头颈部恶性淋巴瘤的临床特征、治疗和预后。方法:回顾性分析116例头颈部恶性淋巴瘤患者的临床资料。头颈部淋巴瘤发病部位以颈部最多,为46例(39.7%),其次是腭及扁桃体27例(23.3%)。临床表现依部位不同而不同,首发症状以颈部无痛性包块最常见。首次就诊误诊43例,误诊率为37.1%。116患者主要采用综合治疗和单纯化疗。结果:Ⅰ、Ⅱ期98例中,失访11例,余87例存活时间超过1年者51例,超过3年者24例,超过5年者12例;Ⅲ、Ⅳ期18例中,失访3例,余15例半年后均死亡。结论:头颈部恶性淋巴瘤的临床表现复杂多样,无特异性,极易误诊,活检是确诊的主要手段。本病主要采用综合治疗,临床分期对预后有重要价值。Objective：To explore the clinical feature,treatment and prognosis of malignant lymphoma in head and neck. Method：One hundred and sixteen cases with malignant lymphoma in head and neck were retrospectively analyzed. The predilection site was most in head and neck（ 39. 7% ） ,followed by palate and tonsil（ 23. 3% ）. The clinical symptoms was different based on different location,painless mass in neck was mostly seen. The misdiagnosis rate is 37. 1%. The treatment measures mainly included combined modality therapy and chemotherapy. Result：Among 98 cases,of stage ⅠandⅡ,the survival time of 51 cases was more than one year,24 cases were more than 3 years,12 cases were more than 5 years. Eleven patients were lost to follow-up. Among 18 cases,of stage Ⅲ and Ⅳ,3 patients was lost to follow-up,the other 15 cases were dead after half a year. Conclusion：clinical feature of malignant lymphoma in head and neck is nonspecific and complicated,misdiagnosis most easily occurs. Biopsy is the most valuable in the diagnosis of malignant lym-phoma. Combined modality therapy is the mainstay of treatment in malignant lymphoma. The clinical stage classification is important for prognosis.

关 键 词：头颈部肿瘤 恶性淋巴瘤 综合治疗 

分 类 号：R739.91[医药卫生—肿瘤]