轻链比值和免疫球蛋白含量测定在诊断轻链病中的重要意义  

THE IMPORTANT SIGNIFICANCE OF THE MEASUREMENT OF LIGHT CHAIN RATIOS AND IMMUNOGLOBULIN IN DIAGNOSIS OF LIGHT CHAIN DISEASE

作　　者：王兰兰[1] 李立新[1] 冯伟华[1] 张瑞薇[1] 

机构地区：[1]华西医科大学附属第一医院临床免疫实验室

出　　处：《免疫学杂志》1999年第1期46-48,共3页Immunological Journal

摘　　要：用速率散射比浊测定２６例轻链病（ＬｉｇｈｔＣｈａｉｎＤｉｓｅａｓｅ，ＬＣＤ）血清、尿液中ＩｇＧ、Ａ、Ｍ和轻链κ、λ含量并计算重链／轻链比值和κ／λ比值。结果表明：血清ＩｇＧ含量均明显低于正常对照（Ｐ＜０．０１）；血清κ或λ含量高于或等于正常对照，但κ／λ比值异常，轻链蛋白总和大于重链蛋白总和；尿液中异常升高的κ或λ轻链含量高于血清同一轻链水平（Ｐ＜０．０１）；ＬＣＤ以λ型多于κ型，λ型血清和尿液中κ／λ比值明显小于１，而κ型血清和尿液中κ／λ比值明显大于２。轻链蛋白是ＬＣＤ患者肾功能损害的重要致病因素，测定血清、尿液Ｉｇ和轻链含量并计算κ／λ比值是诊断ＬＣＤ和判断预后的重要依据。The levels of immunoglobulin,light chain,heavy chain/light chain ratio and Kappa/Lambda light chain ratio in serum and Kappa/Lambda ratio in urine were measured in 26 cases with light chain disease(LCD)by mephelometry method.The results showed that 1.The levels of immunoglobulins in serum of LCD were much lower than healthy controls( P <0.01).2.Although the levels of Kappa or Lambda in serum might be higher than or the same as healthy controls,Kappa/Lambda ratio was abnormal and total concentration of light chains was more than heavy chains( P <0.01).3.The concentration of abnormal Kappa or Lambda light chains in urine was more than the same light chain in serum of LCD( P <0.01).4.The Lambda type were more often present than Kappa type in LCD,all Kappa/Lambda ratios in serum and urine were less than 1 especially the Lambda type,but Kappa/Lambda ratios in serum and urine were more than 2 especially the Kappa type.Light chain protein play an important role in renal failure in LCD.The measurement of serum light chain and immunogolobulin are important to LCD diagnosis and prognosis .

关 键 词：轻链病 к/λ比值 骨髓肿瘤 诊断 免疫球蛋白 

分 类 号：R733.304[医药卫生—肿瘤]