以蛋白酶抑制剂或非核苷类逆转录酶抑制剂为主的方案治疗HIV/HCV合并感染患者的临床疗效比较  

Comparison of effectivity in using NNRTIS- based regimens and PIs in HIV/HCV co-infected patients

作　　者：孙洪清[1] 黄琴[1] 王江蓉[1] 张仁芳[1] 沈芳[1] 邬敏[1] 周晓民[1] 董婕[1] 陈良[1] 蔡卫平[2] 

机构地区：[1]上海市公共卫生临床中心,201508 [2]广州市第八人民医院

出　　处：《临床内科杂志》2010年第6期403-405,共3页Journal of Clinical Internal Medicine

摘　　要：目的 比较以蛋白酶抑制剂（PIs）或非核甘类逆转录酶抑制剂（NNRTIs）为主的方案治疗HIV/HCV合并感染患者的临床疗效.方法 将CD4＋T淋巴细胞≤350/mm3的100例HIV/HCV合并感染患者随机分为2组,每组各50例,分别接受以PIs或NNRTIs为主的方案治疗,观察CD4＋ T淋巴细胞计数和HIV RNA载量等指标的变化.结果 治疗后两组患者的HIV RNA均下降（P＜0.01）,外周血CD4＋T淋巴细胞计数均有不同程度的升高（P＜0.01）,两组比较差异无显著性（P＞0.05）.结论 以PIs或NNRTIs为主的治疗方案治疗HIV/HCV合并感染者均有效.Objective To compare the effectivity in using based on NNRTIS and PIs in HIV / HCV co-infected patients. Methods One hundred HIV/HCV co-infected patients were divided into two groups when their CD4＋ T-lymphocyte count ≤ 350/mm3. One group received NNRTI- based regimens, the another received PI-based regimens, to observe their laboratory result（ CD4＋ T lymphocyte count, HIV virus load ）. Results After received treatment, the level of HIV-1 RNA in all patients was dropped （ P 〈 0.01 ）, the count of CD4＋ T-lymphocyte was increased differently（P 〈0.01 ） , no significant difference in the two groups（ P 〉 0.05 ）. Conclusions It was effective in using NNRTIS- based regimens or PIs in HIV/HCV co-infected patients.

关 键 词：蛋白酶抑制剂 非核苷类逆转录酶抑制剂 HIV/HCV合并感染 

分 类 号：R512.91[医药卫生—内科学]