125例鼻咽癌后程三维适形放疗的预后分析  

Prognosis analysis on 125 cases of nasopharyngeal carcinoma treated with later course three-dimensional conformal radiotherapy

作　　者：黄江琼[1] 黎福祥[1] 李龄[1] 王晓敏[1] 杨超凤[1] 潘朝阳[1] 

机构地区：[1]广西医科大学肿瘤医院放疗科,南宁530021

出　　处：《中国癌症防治杂志》2010年第2期116-119,共4页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

摘　　要：目的对初治鼻咽癌患者后程三维适形放射治疗疗效及其影响因素进行分析,以评价该疗法的可行性。方法对1999年1月至2007年12月在本院接受后程三维适形放疗的125例鼻咽癌进行回顾性分析,计算局部控制率、无远处转移生存率、无瘤生存率、总生存率及咽旁间隙、颅底骨质受侵的生存率。结果全组3、5、10年局部区域控制率分别为是98%、95%、94%,无远处转移生存率为96%、94%、86%,无瘤生存率分别为98%、97%、89%,总生存率为93%、86%、78%。咽旁间隙、颅底骨质受侵的3、5、10年生存率分别为98.0%、94.0%、92.0%和89.0%、79.0%、50.0%。结论初治鼻咽癌采用后程三维适形放疗能取得较好的疗效,即使是在咽旁间隙、颅底骨质受侵时仍有较好的生存率,在费用增加不大的情况下较常规放疗能获得更好的治疗效益比,是一种可选择的较好疗法。Objective To analyze the therapy effect and influence factor of late course three-dimensional conformal radiotherapy（3DCRT）on untreated patients with nasopharyngeal carcinoma（NPC）,and to evaluate the feasibility of this therapy.Methods 125 untreated patients with NPC that received late course 3DCRT from January 1999 to December 2007 were retrospectively analyzed,by calculating the local control rate,distant metastasis-free survival rate,tumor-free survival rate and overall survival rate.The overall survival rate of patients with parapharyngeal space invasion or skull base invasion was also calculated.Results The 3-,5-and 10-year local control rates were 98%,95% and 94%,respectively.The distant metastasis-free survival rates were 96%,94% and 86%,respectively.The tumor-free survival rates were 98%,97% and 89%,respectively.The overall survival rates were 93%,86% and 76%,respectively.Overall survival rates with parapharyngeal space invasion or skull base invasion were 98.0%,94.0%,92.0% and 89.0%,79.0%,50.0% for 3-,5-and 10-year,respectively.Conclusions There is satisfactory effect of late course 3DCRT on the untreated patients with NPC.There is still good survival rate even when the patients were with parapharyngeal space invasion or skull base invasion.3DCRT could improve the treatment benefit ratio without obviously increase the costs comparing to that with conventional radiotherapy.The late course 3DCRT is a good selection for the untreated patients with NPC.

关 键 词：鼻咽肿物 三维适形放疗 肿瘤浸润 预后 

分 类 号：R739.63[医药卫生—肿瘤]