血清ACE与肝功能指标联合检测在肝病诊断中的临床应用  

Clinical Application of Serum ACE and Liver Function Indicators for Joint Detection in Liver Disease Diagnosis

作　　者：闫福堂[1] 王华[2] 苏宝凤[1] 袁军[1] 任健康[1] 

机构地区：[1]陕西省人民医院检验科,西安710068 [2]陕西省临床检验中心,西安710068

出　　处：《现代检验医学杂志》2010年第3期75-77,共3页Journal of Modern Laboratory Medicine

摘　　要：目的检测不同肝病中血清血管紧张素转化酶（ACE）活性水平，探讨ACE与肝功能指标联合检测在肝病诊断中的临床价值。方法采用日立7170A全自动生化分析仪对不同肝病组及正常对照组血清ACE及部分肝功能指标（ALT，AST，TBIL，DBIL，ALP和GGT）进行检测，并计算阳性检出率。结果血清ACE活性除阻塞性黄疸（31．17±8．56U／L）低于正常对照组（39．25±14．75U／L）（F=9．685，P〈0．05）外，其余各组均明显高于正常对照组（P〈0．01）。肝病组之间，慢性活动性肝炎组（93．68±22．52U／L）、肝硬化组（91．59±21．13U／L）显著高于急性肝炎组（69．65±19．23U／L）和慢性迁延性肝炎组（70．22±18．29U／L）（P〈0．01）。阳性检出率分别为ACE48．5％，ALT52．2％，AST40．1％，TBIL38．3％，DBIL37．0％，GGT41．5％和ALP39．7％。即ACE与ALT基本一致（P〉0．05），却明显高于其他指标（P〈0．05）。结论血清ACE活性检测或联合肝功能指标检测有助于肝病的诊断或鉴别诊断、疗效观察及预后判断。Objective To examine serum ACE in different liver disease and discuss the clinical value of ACE and liver function indicators for joint detection in liver disease diagnosis. Methods Using Hitachi 7170A automatic biochemical analyzer to detect serum ACE and some indicators of liver function （ALT, AST,TBIL,DBIL ,ALP and GGT） in different liver disease groups and normal control group,and calculated the positive rate. Results Serum ACE activity in addition to obstructive jaundice （31.17±8.56）U/L was significantly lower than the control group （39.25±14.75U/L） （P〈0. 05） ,the other groups were significantly higher than the normal control group （P〈0.01）. Among liver disease groups, chronic active hepatitis group （93.68 ±22.52U/L）,liver cirrhosis group （91.59±21.13U/L） was significantly higher than acute hepatitis group （69. 65±19. 23U/L） and chronic persistent hepatitis group （70. 22±18.29U/L） （P〈0. 01）. The rate of positive was ACE 48.5% ,ALT 52.2% ,AST 40. 1% ,TBIL 38.3% ,DBIL 37.0% ,GGT 41.5% and ALP 39.7% respectively. ACE basically consistent with the ALT （P〉0. 05）,but was significantly higher than other indicators （P〈0. 05）. Conclu- sion Detection of serum ACE,or in combination with other liver function test can be useful indicators of the diagnosis or differential diagnosis of liver disease ,efficacy observation and prognosis.

关 键 词：血管紧张素转化酶 肝功能指标 联合检测 阳性检出率 肝病 

分 类 号：R575[医药卫生—消化系统] R446.112[医药卫生—内科学]