消旋山莨菪碱滴眼液(信流丁)对青少年近视的临床疗效分析  

Analysis on the clinical efficay of Xin Liu Ding(Raceanisodamine) Eye Drops on incipient juvenile myopia

作　　者：于青[1] 孟浩[1] 叶盛[1] 董世奇[1] 王玲[1] 

机构地区：[1]上海瑞金医院瑞视眼科,上海200025

出　　处：《上海医药》2010年第7期328-330,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:评价消旋山莨菪碱滴眼液(信流丁)对青少年初发性近视的临床疗效。方法:临床随访30例(60眼)10～15岁近视眼初发的患者,给予信流丁滴眼液,分别于用药前及用药1个月、3个月和6个月检测受检眼裸眼视力、等效屈光度、眼压、眼轴长度等数值变化,并记录用药后不良反应。结果:受检者用药前裸眼视力平均为0.34±0.19,用药后1个月,裸眼视力较前明显提高至0.52±0.21(P<0.001),等效屈光度相应降低(P<0.001)。用药3个月视力及等效屈光度继续改善(P<0.05)。但用药6个月与3个月之间差异无显著性(P>0.05)。用药前后患者眼压无明显改变,用药6个月眼轴长度平均增长0.11mm,无明显不良反应。结论:信流丁滴眼液对青少年初发性近视有良好控制作用,无明显不良反应。Objective： To evaluate the clinical efficacy of Xin Liu Ding （Raeeanisodamine） Eye Drops on incipient juvenile myopia. Methods： Thirty younger subjects （60 eyes） with incipient myopia aging from 10-15 years old were followed up. Xin Liu Ding was given to all the subjects. The alteration in uncorrected visual acuity, spherical equivalent, intraocular pressure and axial length were tested and adverse reactions were recorded at 1 month, 3 months, and 6 months after drug administration. Results： The average uncorrected visual acuity of the younger subjects was 0.34 ± 0.19, and was markedly elevated to 0.52 ± 0.21 at 1 month after drug therapy. The difference was significant （P 〈 0.001）. The spherical equivalent values decreased correspondingly （p 〈 0.001）. It was continuously improved at 3 months after drug therapy （P 〈 0.05）. But the spherical equivalent at 6 months had no difference with that at 3 months （P 〉 0.05）. The intraocular pressm＇e had no significant difference before and after drug administration. The axial length increased by 0.11 mm averagely at 6 months. No adverse reaction was observed. Conclusion： Xin Liu Ding Eye Drops may control the incipient juvenile myopia properly and has no significant adverse reactions.

关 键 词：信流丁 消旋山莨菪碱 青少年近视 治疗 

分 类 号：R778[医药卫生—眼科]