具有家族背景大肠癌34例临床分析  

Clinical analysis of 34 cases of the large intestine carcinoma with familial predisposition.

作　　者：吴保平[1] 张亚历[1] 张振书[1] 张立力[1] 周殿元[1] 

机构地区：[1]第一军医大学南方医院消化病研究所

出　　处：《中国实用外科杂志》1999年第1期40-42,共3页Chinese Journal of Practical Surgery

基　　金：军队大肠癌九五攻关课题资金;广东省自然科学基金

摘　　要：目的了解具有家族背景大肠癌的临床特点，为大肠癌的筛检提供线索。方法对４１６例大肠癌进行家系调查，对其中３４例具有家族背景大肠癌的家系、临床资料及病理组织学表现进行分析。结果具有家族背景大肠癌占同期大肠癌的８２％。与无家族史的散发性大肠癌相比，其发病年龄显著提前，右半大肠癌、大肠外癌及低分化癌的发生率均显著增高（Ｐ＜００５）；多原发癌的发生及转移复发与家族史无明显关系（Ｐ＞００５）。Objective\ In order to afford the clues for screening high-risk relatives of colorectal cancer(CRC)in clinic,we evaluated the clinical characteristics of CRCs with familial predisposition.Methods\ By surveying pedigrees in 416 cases of CRC patients,the pedigree,clinical archives and pathological phenotype of CRCs with familial predisposition were analyzed.Results\ The patients with familial predisposition(except FAP)came out to be 34 cases(8 2%).In contract with 40 cases of sporadic CRCs in the corresponding period,the patients' age at onset was younger(47 1 vs 59 9).The incidence of proximal colon cancer,complication by extrocolorectal malignancy and poor differentiated cancer was increased significantly(P<0 05).2 cases of hereditary nonpolyposis colorectal cancer(HNPCC)were found.Conclusion\ CRCs with familial predisposition showed some characteristics which were parts of the phenotype in HNPCC.

关 键 词：家族背景 临床特点 大肠肿瘤 

分 类 号：R735.340.2[医药卫生—肿瘤]