牛磺酸对柯萨奇B3病毒感染新生大鼠心肌细胞外向钾电流的影响  

Effects of Taurine on Outward K + Current in Neonatal Rat Cardiomyocytes Infected with Coxsackievirus B3

作　　者：鲍伟胜[1,2,3] 杨英珍[1,2,3] 顾全保 赵剑星 虞勇[1,2,3] 郭棋 

机构地区：[1]卫生部病毒性心脏病重点实验室-上海心血管病研究所 [2]上海医科大学中山医院 [3]中国科学院上海细胞生物学研究所

出　　处：《上海医科大学学报》1999年第1期8-10,共3页Journal of Fudan University(Medical Science)

基　　金：国家"九.五"攻关基金

摘　　要：观察牛磺酸对柯萨奇Ｂ３病毒（ＣｏｘｓａｃｋｉｅｖｉｒｕｓＢ３，ＣＶＢ３）感染新生大鼠心肌细胞外向钾电流（ｏｕｔｗａｒｄｃｕｒｒｅｎｔ，Ｉｏｕｔ）的影响。方法运用全细胞膜片钳技术记录了分离的大鼠心肌细胞外向钾电流，并观察牛磺酸的作用。结果ＣＶＢ３感染可使正常大鼠心肌细胞Ｉｏｕｔ明显增加，牛磺酸对正常大鼠心肌细胞Ｉｏｕｔ无明显影响，但可使ＣＶＢ３感染的Ｉｏｕｔ趋于正常。结论牛磺酸对ＣＶＢ３感染心肌细胞Ｋ＋通道电流的作用可能是其发挥抗心肌损伤作用的机制之一。Purpose To investigate the effect of taurine on outward K + current ( I out ) in neonatal rat cardiomyocytes infected with Coxsackievirus B3 (CVB3).〖WT10.HZ] Methods Using whole cell patch clamp technique, I out was recordered in isolated neonatal rat cardiomyocytes.〖WT10.HZ] Results CVB3 infection increased I out ,taurine had no obvious effect on I out in normal cardiomyocytes,but normalize it in cardiomyocytes infected with CVB3.〖WT10.HZ] Conclusions The effect of taurine on outward K + current in rat cardiomyocytes infected with CVB3 may be one of the mechanisms by which taurine protects cardiomyocytes from damage. 〖WT10.HZ]

关 键 词：牛磺酸 外向钾电流 心肌细胞 柯萨奇B3病毒 

分 类 号：R542.2[医药卫生—心血管疾病] R373.23[医药卫生—内科学]