膀胱癌的血管内皮细胞生长因子表达、微血管计数及其临床意义  

Expression of VEGF and microvessel counts in bladder cancer and the clinical implication

作　　者：赵国范[1] 孙锐[1] 刘武英[1] 吕纯义 

机构地区：[1]天津医科大学病理教研室,300203

出　　处：《中华实验外科杂志》1999年第1期6-7,共2页Chinese Journal of Experimental Surgery

摘　　要：目的寻求与膀胱移行细胞癌预告后相关的新诊断方法。方法以SABC免疫组化及亲和组化法研究83例膀胱移行细胞癌的血管内`皮细胞生长因子（VEGF）表达、微血管计数及其与病理分级。预后的关系。结果BEGF表达强度、微血管计数在Ⅲ与Ⅰ级癌间、在有复发、转移及5年死亡组与无复发、转移组间有极显著性差异（P＜0.01）VEGF表达、微血管计数在Ⅲ级癌组、在有复发、转移及5年死亡组有相关性。结论VEGF是血管形成的重要因子。VEGF高级表达.Objective To investigatic a new diagnostic method for the prognosis of bladder transitional cell cancer. Method Using immunohistochemistry and lectin binding histochemical methods (SABC ), the expression of vascular endothelial growth factor (VEGF) and tumor angiogenesis were studied on archival specimens of 83 cases of human bladder transitional cell carcinoma and 6 cses of normal bladder mucosa , and their relation to the pathological grading and prognosis was analyzed . Result There was a significant difference in the intensity of VEGF staining of microvessel counts between grade Ⅲand grade Ⅰcarcinoma ,of metastatic , recurrent, 5-year death group and the group without metastasis and recurrence(P<0.01).The expression of VEGF was correlated with microvessel counts in grad Ⅲ carcinoma of in cases of metastasis ,recurrence, 5-year death (P <0.05). Conclusion VEGF is an important angiogenic factor ,and high expression of VEGF and microvessel counts may aid in predicting at risk for metastasis, recurrence and 5-year death.

关 键 词：膀胱肿瘤 微血管计数 血管内皮细胞 VEGF 

分 类 号：R737.140.2[医药卫生—肿瘤]