胃癌患者血清胃泌素水平的变化及其作用  

Serum gastrin level and its effect on gastric cancer

作　　者：黄广建[1] 余枫[1] 王德昭[1] 

机构地区：[1]上海医科大学华山医院外科

出　　处：《上海医学》1999年第1期36-37,共2页Shanghai Medical Journal

摘　　要：目的明确胃癌患者血清胃泌素（Ｇｓ）水平变化的原因及其作用。方法测定了１６４例胃癌患者及２７例正常人血清Ｇｓ含量，分析其与胃癌部位、分期及预后之间的关系。结果胃底贲门癌患者血清Ｇｓ水平明显升高，而胃窦癌、胃体癌患者血清Ｇｓ水平与正常人接近。血清Ｇｓ水平随着胃癌临床病理分期的进展而逐步升高。４１例不能切除的胃癌中，生存期超过１年者血清Ｇｓ水平与生存期不超过１年者接近。结论胃底贲门癌患者血清Ｇｓ水平的升高是一种继发性改变，血清Ｇｓ的水平与胃癌患者的预后无关，血清Ｇｓ并不参与胃癌的生长过程。Objective To study the cause and effect of serum gastrin(Gs) level fluctuation in gastric cancer. Methods The serum Gs contents was determined in 164 cases of gastric cancer and 27 normal persons. We analysed the relationhship between the serum Gs contents and the site, staging and the prognosis of gastric cancer. Results The high serum Gs level was found in cancers of cardia and fundus. The serum Gs contents in cancers of antrum and body are the same as that of normal subjects. The serum Gs level gradually increased with clinicpathological staging of gastric cancer. The serum Gs contents was the same in those of survired more than one year as those survied less than one year. Conclusion The highserum Gs level is a secondary change in gastric cancer. The prognosis of the patients is not correlated with the serum Gs level in gastric cancer. The serum Gs does not take part in the growth of gastric cancer.

关 键 词：胃泌素 胃肿瘤 血清 

分 类 号：R735.702[医药卫生—肿瘤]