蛋白质组学在肝癌发生机制及诊治中的作用  

Role of proteomics in exploring the pathogenesis,diagnosis and treatment of hepatocellular carcinoma

作　　者：撒忠秋[1] 秦建民[1] 倪雷[1] 

机构地区：[1]上海中医药大学附属普陀医院普外科,上海市200062

出　　处：《世界华人消化杂志》2010年第15期1521-1524,共4页World Chinese Journal of Digestology

基　　金：上海市普陀区科委重点基金资助项目;No.B84~~

摘　　要：原发性肝癌的发生、发展涉及一系列多基因参与、多步骤协同的复杂过程,通过DNA序列无法解释所有的生物功能,同样的基因组却表达出不同的蛋白质,显示出不同的生物学功能.通过检测肝癌细胞、组织及外周血清蛋白质表达谱,深入开展肝癌发生、发展、复发与转移相关蛋白质结构和功能的研究,对于阐明肝癌发病机制以及研究新的肝癌诊断与治疗方法,具有重要的研究意义和应用价值.The development and progression of primary liver cancer are a very complicated process that involves multiple genes and steps. DNA sequencing can not thoroughly reveal the biological function of genes since a single gene can encode multiple proteins with distinct functions. The protein profiles of liver cancer cells,tissue and peripheral serum can be determined to analyze the structure and function of proteins involved in the development,progression,recurrence and metastasis of primary liver cancer. Proteomics plays an important role in exploring the pathogenesis,diagnosis and treatment of hepatocellular carcinoma.

关 键 词：蛋白组学 肝癌 机制 诊断 治疗 

分 类 号：R735.7[医药卫生—肿瘤]