创伤应激与肝细胞凋亡  

Traumatic stress and hepatocyte apoptosis

作　　者：廖永晖[1] 千年松[1] 张毅[1] 窦科峰[1] 

机构地区：[1]中国人民解放军第四军医大学西京医院肝胆外科,陕西省西安市710032

出　　处：《世界华人消化杂志》2010年第15期1569-1576,共8页World Chinese Journal of Digestology

基　　金：全军医药卫生科研基金资助项目;No.08Z030~~

摘　　要：创伤会使机体产生应激,在多种因素作用下,可能促使细胞凋亡导致病理损伤,创伤应激致细胞凋亡的机制复杂,仍有很多存在争议的问题,尤其是对那些非神经系统器官而言.临床上很多肝脏疾病均受应激因素的影响,导致肝细胞凋亡而产生肝损伤.目前应激损害研究主要集中在应激对心理造成的损害,而对肝、脑、肺、肾等实质脏器的损害研究不多,机制尚不明确.肝脏是人体新陈代谢的总枢纽,是严重应激损伤的核心靶器官,受创伤应激后的应激性高血糖、钙超载、氧化应激、缺血再灌注、炎性损伤和免疫抑制等因素影响,可发生肝细胞凋亡等病理性损害,故研究创伤应激与肝细胞凋亡的内在联系具有重要意义.Trauma can cause stress in organisms and may promote cell apoptosis and lead to pathological damage. A variety of factors are involved in this process. The mechanisms responsible for traumatic stress-induced apoptosis are complex and controversial,especially in non-nervous organs. The liver plays a key role in metabolism and is one of the target organs of severe stress. Stressinduced hyperglycemia,calcium overload,oxidative stress,ischemia/reperfusion,inflammatory response,and immunosuppression caused by traumatic stress may lead to hepatocyte apoptosis. Thus,it is of great signifi cance to explore the relationship between traumatic stress and hepatocyte apoptosis.

关 键 词：创伤应激 凋亡 应激性肝损害 

分 类 号：R363[医药卫生—病理学]