补体与脂肪肝研究进展  

Advances in understanding the role of complement in the pathogenesis of fatty liver disease

作　　者：王燕[1] 杨耀娴[1] 

机构地区：[1]内蒙古科技大学包头医学院第二附属医院消化病研究所,内蒙古自治区包头市014030

出　　处：《世界华人消化杂志》2010年第15期1577-1581,共5页World Chinese Journal of Digestology

摘　　要：脂肪肝(fatty liver disease,FLD)存在脂肪组织和肝脏等的免疫功能紊乱,补体参与了肝脏脂质沉积发生发展的全过程.肝脂肪变性时过多的脂肪细胞分泌的炎性因子可激活补体,促进脂质沉积并使炎症反应级联放大,继而激发肝细胞线粒体损伤,加重脂质在肝细胞内积存.补体与脂肪肝关系的研究有助于我们对脂肪肝的发病机制进行更深入的认识,C5L2受体拮抗剂的研究有助于研制开发新一代治疗药物.因此需要进一步了解补体在肝脏代谢性应激状态下的免疫机制,从而进一步澄清其在FLD发生发展中的作用,并采取措施预防病变发展.Patients with fatty liver disease （FLD） exhibit various immunologic abnormalities in the adi-pose tissue and the liver. Complement plays an important role in the development of FLD. Innate immune dysfunction in the adipose tissue can lead to abnormal production of adiposederived factors,some of which can activate complement. Complement can not only amplify the inflammatory response and lead to mitochondrial damage,but also inhibit hepatic fat disposal and promote lipid accumulation in hepatocytes. An exploration of the relationship between complement ant the liver can help us have a deep understanding of the mechanisms underlying the pathogenesis of FLD. The antagonists of the C5L2 receptor provide us potential new medicines for FLD. A further study of the role of complement in stress-induced liver remodeling can help clarify the role of complement in the development and progression of FLD.

关 键 词：脂肪肝 补体 炎症 

分 类 号：R575.5[医药卫生—消化系统]